Johns Wort Drug Interaction Reports from FDAs Postmarketing AERS

John s Wort Drug Interaction Reports from FDA s Postmarketing AERS 

Office of Drug Safety, Center for Drug Evaluation and Research (CDER), Eood and Drug Administration, Silver Spring, Maryland, U.S.A. 

Major natural product groups Suggested biological activities 

Dianthrone derivatives Hypericin, pseudohypericin, anthranol, photohypericin, hypericodehydrodianthrone Flavanols Catechin polymers (condensed tannins), leucocyanidin, epicatechin Photodynamic, antidepressant [monoamine oxidase inhibitor (MAOI)], antiviral Astringent, anti-inflammatory, styptic, antiviral 

Capillary-strengthening, antiinflammatory, diuretic, cholagogic, dilates coronary arteries, sedative, tumor inhibition, antitumor, antidiarrheal 

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