Okinawan marine sponge Plakortis

Plakoridine C—A Novel Piperidine Alkaloid from an Okinawan Marine Sponge Plakortis sp. 

Y. Ishiguro, T. Kubota, K. Ishiuchi, J. Fromont, J. Kobayashi, Plakoridine C, a novel piperidine alkaloid from an Okinawan marine sponge Plakortis sp. Tetrahedron Lett. 

Ishibashi, M., Takeuchi, S., and Kobayashi, J. (1993b) Untenone A, a new cyclopentenone from the Okinawan marine sponge Plakortis sp. corresponding to the dienophile in the biosynthesis of manzamenones. Tetrahedron Lett., 34, 3749-3750. 

Murayama, T., Ohizumi, Y, Nakamura, H., Sasaki, T., and Kobayashi, J. (1989) Plakortin, a potent Ca" "" " ATPase activator from the Okinawan marine sponge Plakortis sp. Experientia, 45,898-899. Murray, L.M., Johnson, A., and Crews, P. (1997) Geographic variation in the tropical marine sponge Jaspis c johnstoni an imexpected source of new terpene-benzenoids. /. Oig. Chem., 62, 5638-5643. Myers, B.L. and Crews, P. (1983) Chiral ether glycerides from a marine sponge./. Org. Chem., 48, 3583-3585. 

In 2009 in a study of metabolites from Okinawan marine sponges, Kobayashi and coworkers [96] isolated and characterized a novel piperidine-containing polyketide alkaloid, plakoridine C from a sponge of the genus Plakortis sp. The authors noted that several pairs of resonances in the and NMR spectra were observed with a ratio of approximately 1 1 suggesting an epimeric or isomeric mixture of structures. The mixture was inseparable by semipreparative HPLC so the authors characterized the sample as the mixture. A HMQC spectrum showed the... 

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