Liquid phase organic synthesis

Dabiri M, Salehi P, Baghbanzadeh M, Shakouri M, Otokesh S, Ekrami T, Doosti R (2007) Efficient and eco-friendly synthesis of dihydropyrimidinones, bis(indolyl) methanes, and N-alkyl and N-arylimides in ionic liquids. J Iran Chem Soc 4 393 01 Legeay JC, Eynde JJV, Bazureau JP (2008) Ionic liquid phase organic synthesis (loLiPOS) methodology applied to the preparation of new 3,4-dihydropyrimidine-2(lH)-ones bearing bioisostere group in N-3 position. Tetrahedron 64 5328-5335... 

Iron-exchanged Montmorillonite as an Efficient Acid Catalyst in Liquid-Phase Organic Synthesis... 

General procedure of clav-catalvzed liquid-phase organic synthesis... 

Wentworth, P., Jr. Vandersteen, A. M. Janda, K. D. Poly (ethylene glycol) (PEG) as a Reagent Support The Preparation and Utility of a PEG-triaryl-phosphine Conjugate in Liquid-Phase Organic Synthesis (LPOS), Chem. Commun. 1997, 8, 759. 

Fraga-Dubreuil, J., Famelart, M.-H. and Bazureau, J.P., Ecofriendly fast synthesis of hydrophylic poly(ethyleneglycol)-ionic liquid matrices for liquid-phase organic synthesis, Org. Proc. Res. Dev., 2002,... 

However, continuous reactors, generally fixed bed reactors, which are currently used in gas phase reactions in refining and the petrochemical industry, can also be used for liquid phase organic synthesis in the presence of zeolite catalysts. Better results in terms of catalyst stability are often obtained. However, efforts have still to be made to encourage Organic Chemists to substitute fixed bed reactors, whose setup is relatively simple, to batch reactors, which are virtually the only devices used in academic organic chemistry. 

Wentworth P Jr, Vandersteen AM, Janda KD, Polyethylene glycol) (PEG) as a reagent support the preparation and utility of a PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS), Chem. Common., 759-760, 1997. 

Reed NN, Janda KD, Stealth stars polymers A new high loading scaffold for liquid-phase organic synthesis, Org. Lett., 2 1311-1313, 2000. 

A microwave dielectric heating assisted TSIL phase synthesis [45] of 1,4-dihydropyridines, 3,4-dihydropyrimidin-2(lH)-ones, pyridines and polyhydroquinolines using a TSIL as a soluble support was described. The efficiency of the ionic liquid phase organic synthesis (loLiPOS) methodology was demonstrated by using a one-pot three-component condensation. The stmcture of the intermediates... 

Advances in liquid-phase organic synthesis using functional ionic liquid as supports 07CJO1188. 

A.G. Livingston, L. Peeva, S. Han, D.A. Nair, S.S. Luthra, L.S. White, L.M. Freitas dos Santos, Membrane separation in green chemical processing - solvent nanofiltration in liquid phase organic synthesis reactions, Ann. N.Y. Acad. Sci., 984 (2003) 123-141. 

Costantino, U., Curini, M., Montanaii, R, Nocchetti, M., Rosati, O. 2008. Hydrotalcite-like compounds as heterogeneous catalysts in liquid phase organic synthesis. II. Preparation of 4H-chromenes promoted by hydrotalcite doped with hydrous tin(IV) oxide. Microporous andMesoporous Materials 107(l-2) 16-22. 

Gravert and co-workers (9) used parallel synthesis to design polymeric supports for liquid-phase organic synthesis. In this work, three polymerization... 

In addition to these biomedical applications, PEG also serves as an inert support in liquid-phase organic synthesis or as a polyelectrolyte in the presence of salts. ... 

In addition, Bazureau et al. [250] also report the solvent-free synthesis of N-3 functionalized 3,4-dihydropy rimidin-2-(lH)-ones (DHPMs) 159 following an "ionic liquid-phase organic synthesis" (loLiPOS) protocol based on Biginelli condensation (Scheme 85). The tactic involves the attachment of 3,4-DHPM 155 on the ILP-bound acetoacetates in the first step followed by functionalization with 1,2,4-oxadiazole using aliphatic carboxylic anhydrides. 

H. Hakkou, J.J.E. Vanden, J. Hamelina, J.P Bazureau, Ionic liquid phase organic synthesis (loLiPOS) methodology applied to the three component preparation of 2-thioxo tetrahydropyrimidin-4-(lH)-ones rmder microwave dielectric heating. Tetrahedron 60 (2004) 3745-3753. 

Most recently. Fan s group [66] readily synthesized a series of chiral diphosphane-functionahzed Janus dendrimers (up to 16 BNIAP units, 39) by using liquid-phase organic synthesis with the third-generation Frechet-type polyether dendron as the soluble support. The ruthenium complexes of these dendritic ligands were... 

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