Isothiazoles, literature reviews

Regarding other isothiazole derivatives, different activities have been claimed such as antimicrobial, antibacterial, antifungal, antiviral, antiproliferative and anti-inflammatory activities. They have also been tested as inhibitors of proteases, for the treatment of anxiety and depression, for their action on the 5-HT receptor, and as inhibitors of aldoso reductase. Patented compounds for agrochemical applications are of old interest. This review is concerned with recent results, mainly limited to the last decade. Previous references have been taken into account only if they are of particular relevance or necessary for a better understanding of the text. Furthermore, patents have been included only if they add important information to the existing scientific literature. Articles exclusively dedicated to biological investigations without chemical interest have not been considered. 

Isothiazoles and benzisothiazoles were described in the first edition of Comprehensive Heterocyclic Chemistry (CHEC-I) <84CHEC-i(6)i3i>. The present work summarizes and augments, where appropriate, information from the first edition, but concentrates very much on literature published since 1982. Wherever possible, information is arranged in a similar format to that used in the first edition to facilitate comparisons. The chemistry of isothiazoles is regularly reviewed in Progress in Heterocyclic Chemistry, and specific subjects are discussed occasionally in Advances in Heterocyclic Chemistry, for example benzisothiazoles <85AHC(38)105> and aromaticity <93AHC(56)303>. 

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