Isosorbide dinitrate pharmacokinetics

Sporl-Radun S, Betzien G, Kaufmann B, Liede V, Abshagen U. Effects and pharmacokinetics of isosorbide dinitrate in normal man. Eur J Qin Pharmacol 1980 18(3) 237 4. 

Keller-Stanislawski B, Marschner JP, Rietbrock N. Pharmacokinetics of low-dose isosorbide dinitrate and metabolites after buccal or oral administration. Arzneimittelforschung 1992 42 17-20. 

Other nitrates are similar to nitroglycerin in their pharmacokinetics and pharmacodynamics. Isosorbide dinitrate is another commonly used nitrate it is available in sublingual and oral forms. Isosorbide dinitrate is rapidly denitrated in tbe liver to isosorbide mononitrate, which is also active. Isosorbide mononitrate is available as a separate drug for oral use. Several other nitrates are available for oral use and, like the oral nitroglycerin preparation, have an intermediate duration of action (4-6 hours). Amyl nitrite is a volatile and rapidly acting vasodilator that was used for angina by the inhalational route but is now rarely prescribed. 

Sodium nitroprusside or hydraiazine infusions can reduce serum digoxin levels, but the importance of this is uncertain. Isosorbide dinitrate did not alter digoxin pharmacokinetics in one study. 

Improved Method for the Rapid Determination of Isosorbide Dinitrate in Human Plasma and Its Application in Pharmacokinetic Studies J. Chromatogr. 146(3) 457-464 (1978) CA 90 114757r... 

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