Magnesium isopropyl- chloride

The reaction of 6-methylpyridine-3-carboxylic acid methyl ester with N,0-dimethylhydroxylamine and isopropyl-magnesium chloride in toluene gives the N-methoxyamide derivative (x), which is reduced with diisobutyl aluminium hydride (DIBAL) to afford 6-methylpyridine-3-carbaldehyde (xi). The reaction of the aldehyde (xi) with a phosphite provides the diphenyl phosphonate derivative, which is condensed with 4-(methylsulfonyl)benzaldehyde in the presence of potassium fe/f-butoxide in HF to yield the enimine (xii). Finally, this compound is hydrolyzed with HCI to yield the ketosulfone (ix). 

TRIMETHYLCYCLOHEXEN-1-YL IODIDE. The preparation of DIETHYL (DICHLOROMETHYL)PHOSPHONATE is presented. The use of isopropyl-magnesium chloride instead of butyllithium reduces the amount of by-products and simplifies the purification steps. The preparation of (4-METHOXYPHENYL)-... 

Blicke et al. later (40), have synthesized tropic acid by boiling phenylacetic acid with isopropyl-magnesium chloride in. ethereal solution, and then treating the Gngnard product so formed with formaldehyde. 

SCHEME 22.21 Alkyl group isomerization in the cross-coupling reaction of isopropyl magnesium chloride with chlorobenzene. 

Cross-Coupling Reaction of Isopropyl Magnesium Chloride with Chlorobenzene... 

The examples listed in scheme 4 illustrate the reliability of this remarkable new methodology for catalytic enantioselective C-C bond formation. It should be mentioned that isopropylated products are generated when -propyl magnesium chloride is employed - with good selectivity, as the transformation 40 to 41 indicated. 

To prove this hypothesis a suitable substrate, l-diazo-3-methyl-3-[(E)-phenyldiazenyl]butan-2-one (42) was used. Methyl 2-(2-arylhydrazino)-2-methylpropanoate (39) reacting with a bulky Grignard reagent like isopropyl magnesium bromide gives 4,4-dimethyl-2-phenyl-l,2-diazeti-din-3-one 40 (87TL6577). Oxidation with ferf-butyl hypochlorite converts diazetidinone 40 into 2-methyl-2-(phenyldiazenyl)propanoyl chloride 41, which upon treatment with diazomethane affords the desired diazo ketone 42 (Scheme 8) (98ACE2229). 

CLORURO de ISOPROPILO (Spanish) (75-29-6) see isopropyl chloride. CLORURO MAGNESICO (Spanish) (7786-30-3 anhydrous 7791-18-6 hexahydrate) see magnesium chloride. CLORURO MERCURICO (Spanish) (7487-94-7) see mercuric chloride. CLORURO de MERCURIO y AMONIO (Spanish) (10124-48-8) see mercury ammonium chloride. 

Isopropyl titanium triisostearate Lithium Lithium carbonate Magnesium chloride Magnesium methoxide Manganese dioxide Manganese nitrate 3-Mercaptopropionic acid Mercury Methyl mercaptan... 

Cyclohepta-l,3-diene and ruthenium(iii) chloride trihydrate react in the presence of zinc dust and ethanol to give (329). Complex (329) was also obtained from [(C7Hio)RuCl2] and isopropyl magnesium bromide in the presence of cyclohepta-... 

CaHisN02S, cis-2-Isopropyl-1,3-dioxane-5-carbothioamide, 45B, 319 CaHigOft, Metaldehyde, 4, 253, 281 CaHisOft, 1,4,7,10-Tetraoxacyclododecane, 44B, 279 CaH28Cl2MgOiOf Magnesium chloride hexahydrate - 1,4,7,10-tetraoxa-cyclodecane, 41B, 362... 

When the reaction of isocyanates with isopropyl or -butyl magnesium chloride is conducted in the presence of CpaTiCla normal alkylamides are obtained Isocyanates also insert into Mg-C bonds of polynuclear aluminum-magnesium compounds . ... 

Lithium, THF, chlorodimethylphenylsilane, a solution of isopropyl-magnesium bromide in diethyl ether, 1,2-dichloro-l, 1,2,2-tetramethyldisilane, saturated aqueous ammonium chloride, diethyl ether, brine, anhydrous magnesium sulfate, silica gel, hexane. 

Triaryl phosphates are produced by reaction of phosphoms oxychloride with phenoHc compounds at 100—200°C with magnesium or aluminum chloride catalyst. Past use of cresols and xylenols from coal tar or petroleum is replaced for lower toxicity and cost by synthetic phenoHcs, primarily isopropyl phenol, /-butyl phenol, and phenol itself A range of viscosities is achieved by selection and proportioning of the phenols and their isomers used for the starting material. 

Preparation of 4-aza-S-(N-methyl-4-piperidyll-10,11-dihydro-SH-dibenzo[a,d]cycloheptene-S-ol Add 17.4 g of N-methyl-4-chloropiperidine to a stirred mixture containing 3.2 g of magnesium, 20 ml of anhydrous tetrahydrofuran, 1 ml of ethyl bromide and a crystal of iodine. Reflux for two hours, cool to 30°-35°C and add a solution of 13 g of 4-aza-10,11 -dihydro-5H-dibenzo[a,d] cycloheptene-5-one in 25 ml of tetrahydrofuran. Stir for five hours, remove the solvent by distillation in vacuo and add 250 ml of ether. Add 100 ml of 10% ammonium chloride solution and extract the mixture with chloroform. Concentrate the chloroform solution to a residue and recrystallize from isopropyl ether obtaining 20 g of the carbinol,... 

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