Isopropyl 2-hydroxybenzoate

In addition, Pfister and coworkers investigated 3-hydroxyflavone-6-carboxylic acids as histamine induced gastric secretion inhibitors. After condensing 3-acetyl-4-hydroxybenzoic acid (45) with a variety of aldehydes 46 to deliver the chalcones 47, these purified chalcones were then subjected to the standard AFO conditions to afford flavonols 48 in 51-80% yield. Subsequent alkylation of 48 with methyl iodide or isopropyl iodide followed by saponification of the corresponding esters gave the target compounds. 

There is a recent trend towards simultaneous CE separations of several classes of food additives. This has so far been applied to soft drinks and preserved fruits, but could also be used for other food products. An MEKC method was published (Lin et al., 2000) for simultaneous separation of intense sweeteners (dulcin, aspartame, saccharin and acesulfame K) and some preservatives (sorbic and benzoic acids, sodium dehydroacetate, methyl-, ethyl-, propyl- and isopropyl- p-hydroxybenzoates) in preserved fruits. Ion pair extraction and SPE cleanup were used prior to CE analysis. The average recovery of these various additives was 90% with good within-laboratory reproducibility of results. Another procedure was described by Frazier et al. (2000b) for separation of intense sweeteners, preservatives and colours as well as caffeine and caramel in soft drinks. Using the MEKC mode, separation was obtained in 15 min. The aqueous phase was 20 mM carbonate buffer at pH 9.5 and the micellar phase was 62 mM sodium dodecyl sulphate. A diode array detector was used for quantification in the range 190-600 nm, and limits of quantification of 0.01 mg/1 per analyte were reported. The authors observed that their procedure requires further validation for quantitative analysis. 

Note 4. Scalbert and Monties (1986) have titrated DMF solutions (20 ml) of lignin in concentrations ranging from 0.25 mg to 1.25 mg ml 1 with 0.05 M TnBAH in isopropyl alcohol solution (Fluka Chemical Corp.). p-Hydroxybenzoic acid (2.5 mg in each lignin solution titrated) was used as an internal standard. 

Isopropyl Alcohol 1180 Benzoic Acid 1419 Methyl Hydroxybenzoate... 

Isopropyl-3-methoxy- 1-methylbenzene 342 1-Octanol 388 Propyl p-hydroxybenzoate... 

CAS 4191-73-5 EINECS/ELINCS 224-069-3 Synonyms Benzoic acid, p-hydroxy-, isopropyl ester 4-Hydroxybenzoic acid, 1-methylethyl ester Isopropyl 4-hydroxybenzoate Isopropyl p-hydroxybenzoate 1-Methylethyl-4-hydroxybenzoate... 

Definition Ester of isopropyl alcohol and p-hydroxybenzoic acid Empiricai C10H12O3 Properties M.w. 180.22... 

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