Isoflavones cardiovascular benefits

In spite of the alleged benefits of isoflavones, some studies have produced inconsistent results in relation to their protective effect against cardiovascular diseases (Lin and others 2007 van der Schouw and others 2005 Engelman and others 2005). Some of the inconsistencies are due to the small sample size in most of the studies and to the very marked differences in metabolism among subjects (Erdman and others 2007 Visioli and others 2000). Therefore, no firm conclusions can be drawn. 

Numerous health benefits have been reported or claimed for flavonoids and isoflavones, such as in cancer prevention, cardiovascular effects, and relief of menopausal syndromes. However, concerns have been raised about potential adverse effects, such as enhancement of reproductive organs and anti-thyroid effects. In order to evaluate potential beneficial or hazardous health effects from flavonoids. 

Soy protein intake has been touted for its effects on reducing blood cholesterol and improving risk factors for cardiovascular disease. The recommended daily intake to reap the benefits of soy protein was set at 25 g/day by the FDA following its review of the literature. However, the average dose in numerous clinical trials to elicit an approximate 3% reduction of LDL cholesterol was 50 g/day. This value is double the FDA recommendation and may account for a quarter to one half of a person s daily total protein intake. It also appears that soy may be more effective at lowering cholesterol in hypercholesterolemic individuals. It is of interest to note that soy isoflavones alone do not appear to affect blood lipid concentrations. Inclusion of soy proteins as a trade for other, higher-fat sources of protein may be protective via... 

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