Isocyanates, organic analysis

Isocyanates are derivatised with tryptamine (27) and determined with a dual detection system based on fluorescence and amperometric oxidation Tryptamine and N-co-methyltryptamine (28) were found to be the most promising scavenging reagents for airborne organic isocyanates, before analysis by HPLC with reverse-phase columns and UV detection A personal sampler for airborne isocyanates in workplaces was developed based on 27. ... 

Organic isocyanates in air Lab method with sampling either onto coated glass-fibre filters followed by solvent desorption, or into impingers and analysis using high performance liquid chromatography 25/3... 

Aromatic amines have been shown to be intermediates in the metal catalyzed carbonylation of nitroaromatics to aryl carbamates. Previous research established that the novel bis(methoxycarbonyl) complex, Ru(dppe)(C0)2[C(0)0Me]2, was the most abundant species present during catalysis. In this study, the complete kinetic analysis of the reaction of p-toluidine with Ru(dppe)(C0)2[C(0)0Me]2 established that the C-N bond formed by nucleophilic attack on a metal carbonyl, and that the organic product was removed from the metal by an intramolecular elimination of aryl isocyanate. 

Silica surfaces are the chief source of activity in columns for SFC and, even though many of the columns are well deactivated, the residual silanol sites can lead to tailing or adsorption of analytes. The low surface area of capillary columns is responsible for much higher levels of inertness than their packed counterparts based on silica particles. Capillary columns have been used successfully in the analysis of active compounds, including isocyanates, acid halides, organic acids, amines, peroxides, azo compounds, and many others. The low temperatures required for elution make analysis of active and labile compounds viable. 

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