ISDN - Isosorbide dinitrate

Fig. 2.1 Commonly used organic nitrates and nitrites. GTN, glyceryl trinitrate ISDN, isosorbide dinitrate IAN, isoamyl nitrite IBN isobutyl nitrite.

Isoamyl-N02, amyl nitrite NTG, nitroglycerin ISDN, isosorbide dinitrate ISMN isosorbidemononitrate. 

Fig. 10.6 Schematic diagram of proposed mechanisms by which NO-containing molecules relax vascular smooth muscle (redrawn and modified after Van de Voorde 1991 [7]). NTG, nitroglycerin R-0-N02, organic nitrate ISDN, isosorbide dinitrate ISMN, isosorbide mononitrate R -SH and R"-SH, thiol-containing molecules R -S-S-R disulfides R-OH,...

COMT catecholamine 0-methyl ISDN isosorbide dinitrate... 

The comparison of a hybrid NORM drug versus a comparable combination therapy has rarely been studied in vivo for example, a cocktail of NSAID + ISDN (isosorbide dinitrate) compared to an NO-NSAID. In one case where a comparison was made with NCX 4016 the cocktail was equi-efficacious (Brzozowska et al. 2004). In several hybrid NORM designs, such as JS-K and GT-094, bioactivation to release the warhead bioactivity is contingent upon the presence of the linker (Shami et al. 2003 Zavorin et al. 2001). 

Isosorbide Dinitrate (ISDN) and Isosorbide Mononitrate (ISMN)... 

Brand Name(s) (isosorbide dinitrate) Dilatrate, Dilatrate-SR, ISDN, Isochron, Isordil, Isordil Tembids, Isordil Titradose, Sorbitrate... 

Isosorbide is available in two forms, isosorbide dinitrate (ISDN) and isosorbide mononitrate (ISDN). ISDN is rapidly metabolised in the liver to the active mononitrate. ISDN is only available in oral form. An intravenous formulation of ISDN is available, but is only used for the treatment of acute heart failure. 

Introne interferon alfa isosorbide dinitrate Apo-ISDN, Cedocard, Coradur, Dilatrate-SR, ... 

Compared with placebo, the combination of hydralazine and isosorbide dinitrate (ISDN) reduced mortality in patients receiving diuretics and digoxin (but not ACE inhibitors or /3-blockers). However, another trial comparing the combination with an ACE inhibitor found that mortality was lower in the ACE inhibitor group. Adverse effects (primarily headache and gastrointestinal complaints) with combined hydralazine-ISDN were common, limiting their use in many patients. Patient compliance also was an important issue because hydralazine-ISDN therapy was given four times daily in these trials. Whether less frequent administration provides equivalent benefit is unknown. 

Isosorbide dinitrate Apo-ISDN, Coronex, Isoril, Novosorbide, Sorbitrate... 

We found that the NO-releasing agent isosorbide dinitrate (ISDN, Nitrol ) enhanced antitumor activity of SMANCS/Lipiodol when they were infused into the tumor-feeding bronchial artery of lung cancer using a catheter preceding to the infusion of SMANCS arterially. This ISDN infusion enhanced... 

Nionate. See Ferrous gluconate Niox AK-40. See PEG-200 oleate Niox AK-44. See PEG-400 oleate Niox EO-10. See Cetyl alcohol Niox Ki Series, Niox Ki-29. See PEG castor oil NioxKJ-10. SeeOleth Nipa iSDN. See Isosorbide dinitrate Nipabenzyi. See Benzyiparaben Nipa Biopur 100. See imidazoiidinyi urea Nipabutyi Potassium. See Potassium butyi paraben... 

The oldest class of clinically used NO donors are the organic nitrates (R-ONO2) (Fig. 20.3), which are nitric acid esters of mono and polyhydric alcohols, including glyceryl trinitrate (GTN A.l), pentaerithrityl tetranitrate (PETN A.2), isosorbide dinitrate (ISDN A.3), and isosorbide-5-mononitrate (ISMN A.4). Metabolites of GTN, viz., glyceryl mononitrate (GMN) and glyceryl dinitrate (GDN), are pharmacologically active, but less potent than GTN. 

A number of organic nitrates are potent vasodilators and have been used clinically for over lOOyears, particularly for the relief of the symptoms of angina (Fig. 8.6). The most widely used is glyceryl trinitrate (GTN) but the group includes pentaerythrityl tetranitrate (PETN), isosorbide mononitrate (ISMO) andisosorbide dinitrate (ISDN). 

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