Ischaemia-reperfusion injury muscle

Walker, P.M. (1991). Ischaemia/reperfusion injury in skeletal muscle. Ann. Vase. Surg. 5, 399—402. 

The findings that reperfusion after ischaemia is necessary for NO formation (Lepore etal. 1999) suggests that an inflammatory pathway is responsible for NOS-independent NO formation in ischaemia-reperfusion injury to skeletal muscle. In transient (2 h) focal cerebral ischaemia in rats, infusion of sodium nitroprusside (O.llmg/kg) and spermine/NO (0.36, 3.6 mg/kg) reduced the infarct size (Salom et al. 2000). 

Pang, C.Y. (1990). Ischaemia-induced reperfusion injury in muscle flaps pathogenesis and major source of free radicals. J. Reconstr. Microsuig. 6, 77-83. 

Cinnamophilin has protective activity against reperfusion injury of the ischaemic skeletal muscle in rats. Ischaemia was induced in one hind limb by application of a tourniquet on the proximal thigh the contralateral limb served as an internal control. Of the four-reperfusion groups, only the cinnamophilin group had a smaller triphenyltetrazolium chloride reduction and lower muscle weight gain [302],... 

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