Isatoic acid

Isatin, see Indole Isatoic acid, see Indole l(3/i) -Isobenzofuranone, see Naphthalene Isobutylbenzene, see Butylbenzene, PCB-1242... [Pg.1533]

A quinazolodione provides the nucleus for yet another eompound that inhibits aldose reductase. The sequence for the preparation of this agent starts with the isatoate acid (90-1) from 4-chloroantharanilic acid. Heating the compound with the substituted benzylamine (90-2) results in the formation of the ring-opened amide (90-3) with a loss of carbon dioxide. The ring is then reclosed, this time by reaction with carbonyl diimidazole, to afford the quinolodione (90-4). The anion from the reaction of this last intermediate with sodium hydride is then alkylated with ethyl bromoacetate. Saponification of the ester completes the preparation of zenarestat (90-5) [100]. [Pg.485]

Oxidation of isatin. Two products are possible from Baeyer-Villiger oxidation of isatin (1). Oxidation with K2S208 in sulfuric acid gives only the 1,4-beiuoxazine 2, whereas oxidation with H202-H0Ac gives the anhydride (3) of isatoic acid.1 An earlier preparation of compounds of type 2 involves reaction of o-aminophenols and oxalyl chloride.2... [Pg.331]

Isatin-2-iminooxides lead to isatoic acid derivatives and quinazolinediones by photolysis, while isatin-3-iminooxides are reported to furnish only quinazolinediones. In both cases some isatin is also obtained (Scheme 42). [Pg.36]

Anthranilic acid hydrazides are synthesized from isatoic acid and hydrazines... [Pg.37]

Some isatoic acid anhydrides are readily hydrolyzed during oxidation so that the corresponding A -(2-hydroxyphenyl)oxamidic acids are isolated as products [260], With 7-chloroisatin, treatment with 30% hydrogen peroxide in 5% aqueous sodium hydroxide for 40 min at 65 °C produces chloroanthranilic acid in 78% yield (equation 395) [1168]. [Pg.194]

By oxidation with dilute nitric acid it yields nitrosalicylic acid, and on melting with caustic potash, aniline is formed. By o.xi-dationwith chromic acid in acetic-acid solution anthranilcarbonic acid (Kolbe s Isatoic Acid) [21] is produced ... [Pg.222]

Iron(III)sulfate, 223-224 Isatin, 331 Isatoic acid, 331 Isoatlantolactone, 263, 264 Isobutenyl acetate, 153 Isobutyronitrile, 110 Isocyanates, 14-15 Isoflavones, 410 Isopavine, 217 Isopenams, 325 Isophorone, 197, 198 Isopinocampheylborane, 224 Isoprene epoxide, 4 Isopropenyl phenyl sulfone, 316 Isopropenyltriphenylphosphonium bromide, 225... [Pg.263]

Kolbe2 in his last papers described a compound with the same formula, formed by oxidation of isatin (3) with Cr03, and called it isatoic acid. Meyer3 proved the identity of both compounds, and Niementowski and Rozanski4 were the first to establish the correct formula (1) when they found a new synthesis from anthranilic acid (4) and ethyl chloroformate. [Pg.128]

When heated in toluene certain arylazomethylenetriphenylphosphoranes (prepared from isatoic acids) undergo an intramolecular Wittig reaction to give 3,4,6-trisubstituted cinnolines (Equation... [Pg.64]

Beilstein Handbook Reference) AI3-24983 Benzoic acid, 2-(carboxyamino)-, cyclic anhydride BRN 0136786 N-Carboxyanthranilic acid cyclic anhydride N-Carboxyanthranilic anhydride EINECS 204-2660 HSDB 5017 Isatoic acid anhydrtde Isatoic anhydride NSC 104662. [Pg.342]

Isatoic acid anhydride. See Isatoic anhydride Isatoic anhydride... [Pg.2185]

CAS 118-48-9 EINECS/ELINCS 204-255-0 Synonyms Anthranilic acid N-carboxylic acid anhydride 1H-Benzo[D][1,3] oxazine-2,4-dione 2H-3,1-Benzoxazine-2,4(1H)-dione lA Isatoic acid anhydride... [Pg.2185]

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