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Isatin-3-thiosemicarbazone

Isatin reacts with formaldehyde and a variety of amines in the Mannich reaction to give compounds of type 42.181-193a A similar reaction takes place with isatin-3-thiosemicarbazone,185,187 or 42 can react with thiosemicarbazide to give a similar product.192 In the absence of an amine, isatin181 and substituted isatins157,193a with form-... [Pg.14]

Isatin-3-hydrazones react with aldehydes to give 91.157,314 Compound 91 (R = H, Ar = 2-(5-nitrofuryl)) has also been prepared by reaction of isatin with 5-nitrofurfuraldehyde hydrazone.314 Ammonium isothiocyanate, and 86 gave isatin-3-thiosemicarbazones.318... [Pg.28]

A very large variety of isatins reacted with thiosemicarbazides to give isatin-3-thiosemicarbazones (98).29 58,146,151,155 156,166,181,182,192,193a,2°0, 304.312.315.326-344 rp te impetus for the bulk of this work is the fact... [Pg.30]

An excess of isatin with thiocarbohydrazide gives 106.384 The syn isomer of isatin-3-thiosemicarbazone predominates while isatin-3-semicarbazone exists in the anti form.305 Treatment with acid or warming converts this anti form into the syn isomer, while base causes the reverse isomerization.344 4-Methylisatin-3-semicarbazone exists as the syn isomer.344... [Pg.33]

A number of cyclization reactions have been carried out with isatin derivatives of this series. Isatin-3-thiosemicarbazone with chloroacetic acid, sodium acetate, acetic acid, and aldehydes gave 107.392,393... [Pg.33]

Isatin /3- thiosemicarbazones (97) readily give triazinoindoles (98) (72JMC277). Deprotonation of the amide (99) leads to ring closure on to the urethane carbonyl group to give (100). In a similar reaction (101 to 102) the lower reactivity of the t- butyl ester induces ring closure in the required direction (78CPB3080). [Pg.515]

The stereochemistry of isatin-3-thiosemicarbazone-5-sulfonate was studied in aqueous solution, and in acidic pH the Z isomer was determined to be the most stable, but after... [Pg.45]

Isatin-3-thiosemicarbazones are useful substrates for the synthesis of other 3-... [Pg.48]

Due to its ability to bind ferric ions, isatin-3-thiosemicarbazone can be used to form magneto-polymer composites with poly (vinyl chloride)... [Pg.98]

A variety of metal complexes of isatin-3-thiosemicarbazones 279.386-390 and isatin-3-semicarbazones have been prepared. [Pg.33]

Treatment of isatin-3-thiosemicarbazone and N-methyl-isatin-3-thiosemicarbazone with lA alkali gave 108 which on treatment with alkali and iodine gave 109, and with alkali and methyl iodide gave no. - Ring opening also took place in the preparation of 108 (R = Me). Treatment of 108 (R = Me) with... [Pg.33]

Reaction of aromatic or heterocyclic amines with formaldehyde and urea or phenylthioureas gave 2-(oxo)thioxohexahydro-l,3,5-triazines 90. Regioselective cyclization and isomerization of propargylthio-l,2,4-triazinones were achieved to give the fused heterocycles 91-93. Cyclization of isatin 3-thiosemicarbazones gave 94 which can be alkylated to 95 . The imidazotriazepines 96 were obtained from heating a mixture of hydrazide and ortho-ester. [Pg.11]

Methisazone [1910-68-5] C10H10N4OS (l-methyl-3-thiosemicarbazone of 2-oxoindole, (7), one of the more active in the isatin-3-thiosemicarbazone [487-16-1] series, has been used in the treatment and prevention of smallpox and vaccinia infections that develop as complications of smallpox vaccination... [Pg.304]

W-indoie-2,3-dione, 3-thiosemicarbazone isatin, 3-thiosemicarbazone CgHsNzOS 487-16-1 220.261 283 ... [Pg.456]

The barrier to rotation about the C—N bond for 1,1-dimethylselenosemi-carbazide appeared to be slightly higher than that found for its thio-analogue (AF"=11.6 and 11.2kcalmor, respectively) Other papers report on the influence of the substituents R and X on the barrier to rotation of the dimethylamino-group in the pyrazoles (528) the determination of AP (21.1 kcal mol ) for the restricted rotation around the CS—bond in the thiophosphinoylthioformhydrazide (529), and the syn-anti isomerism of isatin /3-thiosemicarbazones. ... [Pg.314]

See other pages where Isatin-3-thiosemicarbazone is mentioned: [Pg.527]    [Pg.57]    [Pg.7]    [Pg.49]    [Pg.356]    [Pg.290]    [Pg.19]    [Pg.31]    [Pg.203]    [Pg.342]    [Pg.46]    [Pg.363]    [Pg.19]    [Pg.31]    [Pg.424]    [Pg.416]    [Pg.403]    [Pg.463]    [Pg.709]    [Pg.451]    [Pg.462]    [Pg.708]    [Pg.493]    [Pg.665]    [Pg.416]   
See also in sourсe #XX -- [ Pg.342 ]



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Isatin

Isatin thiosemicarbazones

Isatin thiosemicarbazones

Isatines

Thiosemicarbazone

Thiosemicarbazones

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