Isaacs’ syndrome

Isaacs syndrome (an acquired neuromyotonia) is caused by autoantibodies directed against 4-aminopyr-idine or a-dendrotoxin-sensitive K+ channels (Kvl.l and Kvl.6) in motor and sensory neurons. The syndromes include muscle twitching during rest, cramps during muscle contraction, impaired muscle relaxation, and muscle weakness due to hyperexcitability of peripheral motor nerves. 

Paraneoplastic sensory neuropathy Lambert-Eaton myasthenic syndrome Neuromyotonia (Isaacs syndrome)... 

Potassium channel antibodies in Isaac syndrome cause neuromyotonia 725... 

Neuromyotonia, or Isaacs syndrome, can occur as a paraneoplastic manifestation [138]. In a study of 60 patients with neuromyotonia, 8 individuals developed lung cancer or malignant lymphoma [139]. Importantly, and in contrast to most other PNS, the tumors presented after the symptoms of nerve hyperexitability, in some cases up to 4 years later. This long latency has also been reported in LEMS with SCLC [140]. 

Neutron-to-proton ratio, 29-30 Newton, 457,635 Newton, Isaac, 136 Nickel hydroxide, 78 Nicotinic acid, 364-365 NIMBY syndrome, 526 Nitric acid acid rain and, 400 acid strength of, 567 commercial use, 76 copper penny dissolving in, 570 production, 570-571... 

Myasthenia gravis Lambert-Eaton syndrome Neuromyotonia (Isaac s syndrome) Intoxications and metabolic diseases... 

Wing, M.G., Moreau, T., Greenwood, J., Smith, R.M., Hale, G., Isaacs, J., Waldmann, H., Lachman, P.J. and Compston, A. (1996) Mechanism of first-dose cytokine-relaease Syndrome by Campath 1-H Involvement of CD 16 (FCyRlll) and CDlla/CD18 (LFA-1) on... 

Wing MG, Waldmann H, Isaacs J, Compston DAS, Hale G. Ex-vivo whole blood cultures for predicting cytokine-release syndrome dependence on target antigen and antibody isotype. Ther Immunol 1995 2 183-90. 

Wing MG, Moreau T, Greenwood J, Smith RM, Hale G, Isaacs J, Waldmann H, Lachmann PJ, Compston A. Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H involvement of CD16 (Fc-yRIII) and CDlla/CD18 (LFA-1) on NK cells. J Clin Invest 1996 98 2819-26. 

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