IRORI system

The hbraries were constructed using the Irori system. For the 10,000-member library, MicroKans were filled with BAL resin by suspending the resin in an isobuoyant suspension (DMF DCE 2 1) and dispensing it with a Packard Multiprobe liquid handler. For the 5000-member library, resin bound scaffold 18 was prepared in bulk and loaded into the MicroKans... 

A very extensive diversification of l,5-benzodiazepin-2-ones with the help of the radiofrequency tagged IRORI system (Discovery Partners International, San Diego, USA) was reported by Herpin et al. [24]. Here, the strategy of template preformation in solution and subsequent derivatization on a soHd phase was pursued. 

Manual sorting of microreactors can become tedious when a large number (more than 1000 2000) of them are used. IRORI s AutoSort -10K Microreactor Sorting System (Figure 13.9) [22, 23]) is designed to solve this... 

In the laboratory we have several automatic and semiautomatic robotic apparatus including the IRORI Nanokan optical encoding system for split- and pool-synthesis (34) and synthesizers from Advanced ChemTech and the MiniBlock from Mettler, Toledo, OFI. 

Figure 12. IRORI AutoSort -10K Microreactor Sorting System.

The synthetic scheme developed for the P-strand template (27.7) has proved to be robust and efficient. Utilizing this chemistry and the IRORI minikan system, we have produced well over 70 000 P-stfand mimetics based on this privileged chemotype (27.7). All compounds are examined for identity and purity by LC-MS, with a success rate of over 85% at a purity level of greater than 80%. ... 

SCHEME 1.3 Benzopyrans synthesized on solid support utilizing a novel selenium linker and IRORI radiofrequency tags, MacroKan technologies, and the NanoKan system. 

In this preliminary study, we used sets of colored glass beads to label the MaeroKans. For larger libraries, we use the full combinatorial system with radio frequency (RF) tags from IRORI (research in progress). 

More recently, noninvasive coding schemes, with nonchemical tags such as radiofrequency memory units, have been used. IRORI Quantum Microchemistry s radiofrequency AccuTag-100 system aims to combine the advantages of both parallel synthesis and split and pool. The system combines glass-encapsulated microchip tags, polymer microreactors, and software, in order to produce a turnkey solution for combinatorial chemistry. 

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