Iron oxide nanoparticles cytotoxicity

Morteza Mahmoudi, Abdolreza Simchi and Mohammad Imani. (2009). Cytotoxicity of Uncoated and Polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles, /. Phys. Chem. C, volume 113, Issue 22, pp 9573-9580. 

Novel magnetic iron oxide nanoparticles coated with polyfethylene imine)-g-poly(ethylene glycol) for potental biomedical application Synthesis, stability, cytotoxicity and MR imaging. International Journal of Pharmaceutics, Volume 408, Issues 1-2,15,p>p 130-137. 

A great number of opposing results have been reported for the cytotoxicity of both bare and surface-modified iron oxide nanoparticles, and the well-known debate on whether iron oxide nanoparticles are biocompatible or toxic at a variety of doses still remains [29]. Similarly, many smdies support that SiO nanoparticles with a size range from the nanometer to submicron are not toxic and SiO has been used as a nontoxic, negative control in cytotoxicity smdies of other nanomaterials [30]. But there are also smdies showing that SiO nanoparticles of 21 and 48 nm can induce oxidative stress, cell damage, and eventually apoptosis in hepatic and myocardial cells [31,32]. 

George, S. et al. (2010) Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano, 4 (1), 15-29. 

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