Iron overload disorder

S. S. Bottomley Secondary iron overload disorders. Seminars in Hematology 35,77(1998). 

M. E. Conrad Introduction iron overloading disorders and iron regulation. Seminars in Hematology is, 1 (1998). 

Iron-Binding Polymers for the Treatment of Iron Overload Disorders... 

McLaren GD, Muir WA, Kellermeyer RW (1981) Iron overload disorders natural history, pathogenesis, diagnosis, and therapy. CRC Crit Rev Clin Lab Sci 19 205-266... 

Deferiprone is the orally active iron chelator that has been most often used for the treatment of iron overload disorders [117]. It will be of interest to test whether deferiprone provides efficacy for AD based on the experimental capacity of chelators to limit APP translation, as has been observed for both desferrioxamine (Fe chelator) and dimercaptopropanol (Hg2+, Cu2+ chelator)(see Table 1). There is controversy concerning the use of deferiprone as... 

Abnormally high iron levels in particular biological compartments can have a profound effect on a number of disease processes. Thus, iron-mediated diseases can be separated into two fundamental categories, systemic and focal iron overload disorders. The systemic disorders are typified by hemochromatosis and transfusional iron overload associated with either hemolytic anemias, such as thalassemia and sickle cell anemia, or bone marrow deficiency, for example, myelodysplasia. Disorders with focal iron sequestration include ischemia-reperfusion injury (5, 6), Parkinson s disease, Alzheimer s disease, and Friedreich s ataxia, to name a few (7, 8, 9,10, 11,12). 

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