Iron, sequestration

Patients with CKD suffer from a decrease in erythropoietin production because erythropoietin is produced mainly in the kidneys.4,5 Finally, in patients with anemia of chronic disease, there is a blunted erythropoietin production as well as a diminished response to erythropoietin.9 Anemia of chronic disease also affects iron homeostasis, causing iron sequestration into storage sites and decreasing the amount available to the rest of the body.9... 

IRON SEQUESTRATION BY SMALL MOLECULES THERMODYNAMIC AND KINETIC STUDIES OF NATURAL SIDEROPHORES AND SYNTHETIC MODEL COMPOUNDS... 

The kinetics and mechanism of iron-siderophore complex formation are influenced by the oxidation state and composition of the first coordination shell of iron. The iron sequestration... 

These general comments regarding iron sequestration kinetics can be placed in the context of the Eigen-Wilkins mechanism for complexation (135). Initial complex formation proceeds by way of the formation of an encounter complex, Fe(H20)g+ L,... 

The implications of these mechanistic studies for our understanding of environmental iron sequestration by siderophores is as follows. The hydroxyl containing aqua ferric ions will tend to form ferri-siderophore complexes more rapidly than the hexaaqua ion and ferrous ion will be sequestered more rapidly than the ferric ion. However, once in a siderophore binding site the ferrous ion will be air oxidized to the ferric ion, due to the negative redox potentials (see Section III.D). This also means that Fe dissolution from rocks will be influenced by mineral composition (other donors in the first coordination shell) as well as surface reductases in contact with the rock, and of course surface area (4,13). 

DCCD and vanadate. This indicates an active process energised by ATP. Ferrozine inhibition of Fe2+ and Fe3+ uptake implied the concerted involvement of both a Fe3+ reductase and FeoB in the uptake of iron supplied as Fe3+. It is concluded that FeoB-mediated Fe2+ represents a major pathway for H. pylori iron sequestration [189], In addition, growth experiments on the human pathogen L. pneumophila using artificial media, as well as replication studies within iron-depleted Hartmannella vermiformis amoebae and human U937 cell macrophages, provided evidence that the FeoB transporter is important for extracellular growth and intracellular infectivity [190],... 

Interactions between ferritin and ceruloplasmin and influence on iron sequestration development of treatment. 

Iron Sequestration by Small Molecules Thermodynamic and Kinetic Studies of Natural Siderophores and Synthetic Model Compounds Alvin L. Crumbliss and James M. Harrington... 

Serum transferrin has a more specialized fimction than simply iron sequestration, transporting iron from sonrces of iron in the body (e g. after absorption throngh the... 

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