Iron Nramp

Thomine, S., Wang, R., Ward, J. M., Crarvford, N. M., and Schroeder, J. I., 2000, Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes, Proc. Natl. Acad. Sci. U.S.A. 97 4991-4996. 

Picard V, Govoni G, Jabado N and Geos P (2000) Nramp 2 (DCTl/DMTl) expressed at the plasma membrane transports iron and other divalent cations... 

Curie C, Alonso JM, Lejean M, Ecker J-R and BeiatJ-F (2000) Involvement of Nramp-1 from Arabidopsis thaliana in iron transport. Biochem J 347 3749-3755. 

In addition, recent developments in our understanding of iron uptake and transport provide strong evidence that these systems may also facilitate uptake and transport of lead. Recent smdies on the intestinal iron transporter, Nramp, suggest that this protein may also be responsible for uptake of lead from the intestines into the bloodstream (469). 

Nramp Natural resistance-associated macrophage protein (iron transporter)... 

In humans, iron is transported across the gut by a series of poorly defined processes. Fe(III), ferric ion, is absorbed via a J03 integrin and mobilferrin, whereas ferrous ion enter the cells via Nramp. Once inside the body, Fe(III) is transported through the serum by transferrin, a protein of molecular weight 63,000 Da. Fe(III) transferrin is recognized by a receptor protein on the cell surface. Via a process known as cell-mediated endocytosis, the Fe(III) transferrin/receptor complex induces the external cell membrane to pucker and eventually form a clatharin-coated vesicle in the cytoplasm. After removal of the clatharin, the vesicle (known as an endosome) becomes... 

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