Simvastatin 4- Irbesartan

A small well-designed study in 14 healthy subjects showed no significant effect of irbesartan on the single-dose pharmacokinetics of total simvastatin acid (7). 

Marino MR, VachharajaniNN, HadjUambris OW. Irbesartan does not affect the pharmacokinetics of simvastatin in healthy subjects. J Clin Pharmacol 2000 40(8) 875-9. 

Irbesartan and telmisartan appear not to alter the pharmacokinetics of simvastatin, fluvastatin does not alter the pharmacokinetics of losartan or its active metabolite, and ohnesartan appears not to interact with pravastatin. 

A study in 12 healthy subjects found that irbesartan 300 mg had no significant effect on the pharmacokinetics of a single 50-mg dose of simvastatin, or its metabolite simvastatin acid, and the combination was well-tolerated. No clinically relevant interaction was noted when telmisartan was given with simvastatin. ... 

Chronic hepatitis was reported in a 58-year-old woman with a history of high blood pressure, hypothyroidism, diabetes, and high cholesterol. The woman had been taking 80 mg of black cohosh extract daily for 1 year along with irbesartan, levothyroxin, simvastatin, and insulin. The liver injury was initially thought to be induced by simvastatin, although discontinuation of simvastatin did not result in a reduction of liver enzyme levels (Pierard et al. 2009). 

---

See also in sourсe #XX -- [ ]

---