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Radionuclides iodine

The main advantage of all iodine radionuclides is their relatively easy introduction into the protein molecule that is to be labeled, whose structure is only slightly changed as a result of the labeling. Iodine binds by electrophilic substitution onto tyrosyl and histidyl residues. [Pg.168]

Table 2. Examples of proteins labeled with iodine radionuclides... Table 2. Examples of proteins labeled with iodine radionuclides...
Serum albumin labeled with an iodine radionuclide was firstly used as a substrate for determining protease activity by Absolon This method was later on modified several times and applied for assaying various proteolytic activities in different materials. Mego et al. injected denaturated I-human %rum albumin into the tail vein of rats and measured the rate of intralysosomal proteolysis on isolated lysosomes containing endocytosed substrate. This method was also used for the determining the intralysosomal pH on the basis of differences found in the rate of I-albumin breakdown in intact and lysed lysosomes C-bovine serum albumin, I-casein or I-albumin have been alternatively used as substrate for measuring the activity of trypsin, chymotrypsin and papain - ). [Pg.199]

LABELING MABS AND PEPTIDES WITH RADIOHALOGENS 6.7.5.1 Iodine Radionuclides... [Pg.892]

The chemistry of iodine radionuclides used in nuclear medicine has been extensively explored. Isotopic exchange procedures, direct iodination approaches (those using chloramine-T and iodogen), and indirect approaches (the Bolton-Hunter method) are but a few of the well-known synthetic strategies to label biomolecules with iodine (24). Some of the most important 1-labeled imaging tracers [1-labeled iodoazomycin arabinoside ( lAZA), 1-labeled vasoactive intestinal peptide ( 1-VlP), etc.] will be discussed in the following sections. [Pg.10]

Finn R. Chemistry appUed to iodine radionuclides. In Welch MJ, Redvanly CS, eds. Handbook of Radiopharmaceuticals Radiochemistry and Applications. Chichester Wiley, 2003 423-440. [Pg.26]

Iodine-129, with a half-life of 1.57 X 10 years, is the longest-lived iodine radionuclide. It originates from both artificial and natural sources. Natural production is estimated to have led to a steady state atom ratio of I to stable I of approximately 10" in the oceans prior to the introduction of man-made sources. As a result of nuclear technology the ratio of environment has increased since... [Pg.44]

The retention of radionuclides within the containment was little accounted for by the RSS, but ranges from little to very substantial because of agglomeration and deposition. This leads to a large over prediction of the iodine risk, but substantial agreement with RSS for some other isotopes. [Pg.316]

Aii, T., S. Kume, S. Takahashi, M. Kurihara, and T. Mitsuhashi, 1990. The effect of the radionuclides from Chernobyl on iodine-131 and cesium-137 contents in milk and pastures in south-western Japan. Japan. Soc. Zootech. Sci. 61 47-53. [Pg.1736]

Kodrich, W.R. andC.A. Tryon. 1971. Effects of season on thyroid release of iodine-131 in free-ranging eastern chipmunks (Tamias striatus). Pages 260-264 in D.J. Nelson (ed.). Radionuclides in Ecosystems. Proceedings of the Third National Symposium on Radioecology. May 10-12, 1971, Oak Ridge, TN. Vol. 1. Available from Natl. Tech. Infor. Serv., Springfield, VA 22151. [Pg.1744]

Keywords phytoremediation, radionuclides, 137-caesium, 90-strontium, 125-iodine, uranium, radium, uranium mill tailings, biomonitoring... [Pg.140]

The reactors at Oklo and Bangombe provide great confidence in the feasibility of radioactive waste isolation. The reactors operated for 800 000 years and after two billion years, most of the radionuclides (except for iodine that has migrated away completely) and/or their decay products have migrated only a few metres. [Pg.84]

Metabolically, radionuclides are handled in the same way as stable elements of the same atomic numher. Thus radioactive iodine simulates stable iodine, being concentrated in the thyroid gland so predictably that its rate of uptake provides an accurate measure of thyroid function. The metabolism of other radionuclides also is sufficiently characteristic so that their patterns of uptake, distribution, translocation, and excretion are similarly predictable. [Pg.22]

While the effects of internally deposited radionuclides are attributable in most instances to the type and energy of the radiations they emit, their transmutation on decay has also been implicated in certain circumstances, e.g., the severe mutagenicity and lethality caused by decay of iodine-125 in 5-iododeoxyuridine-labelled DNA is attributed in part to rupture of the uracil ring following transmutation of the iodine (Stocklin, 1979). [Pg.22]

Fourth, chemicals and, indeed, many radionuclides, e.g., iodine-l3l, often affect primarily only one organ, which may vary among species, whereas external penetrating radiation can affect virtually any organ of the body, depending on the source and energy of the emissions. [Pg.111]

Iodine-129 was the first short-lived radionuclide shown to have been present in the early solar system. It was difficult to prove that the excess 129Xe found by Reynolds (1960) in meteorites was due to the decay of 129I. A means had to be found to show that the excess 129Xe was associated with iodine. Jeffery and Reynolds (1961) solved the problem by... [Pg.540]

Our production parameters for this generator are presented. The Xe-122/l-122 combination, a convenient source of a short-lived (3.6m) positron emitting iodine, is also discussed. Recent developments in rapid iodination procedures will broaden the potential applications of this generator. Finally, preliminary investigations of another generator derived radionuclide that may have promise is described. Tellurium-118 (6d) is the parent of the 3.5 minute positron emitter Sb-118 which may be useful for first pass angiography. [Pg.77]

The only radionuclidic impurity detected in the 1-122 is less than 0.1% radioxenons and other radioiodines, which neither interfere with scintigraphic imaging nor result in a high radiation exposure to the patient. Further improvement of the radioiodine contamination could be attained with an iodine trap between the storage reservoir and the growth chamber. The milking efficiency is about 40%. We consider this generator assembly to be a preliminary version that can be refined considerably. Further details may be obtained from Richards and Ku (8). [Pg.90]

The radionuclides commercially available and most commonly used for a number of the foregoing applications include anhmony-125 banum-133, 207 bismuth-207 bromine-82 cadmium-109, 115 m calcium-45 carbon-14 cerium-141 cesium-134, 137 chlorine-36 chromium-51 cobalt-57, 58, 60 copper-64 gadolimum-153 germanium-68 gold-195. 198 hydrogen-3 (tritium) indium-111, 114 m iodine-125, 129, 131 iron-55, 59 krypton-85 manganese-54 mercury-203 molvbdenum-99 nickel-63 phosphorus-32. 33 potassium-42 promethium-147 rubidium-86 ruthenium-103 samarium-151 scandium-46 selenium-75 silver-110 m sodium-22, strontium-85 sulfur-35 technetium-99 thallium-204 thulium-171 tin-113, 119 m, 121 m. titamum-44 ytterbium-169, and zinc-65. [Pg.1410]


See other pages where Radionuclides iodine is mentioned: [Pg.168]    [Pg.171]    [Pg.883]    [Pg.924]    [Pg.168]    [Pg.171]    [Pg.883]    [Pg.924]    [Pg.324]    [Pg.670]    [Pg.1686]    [Pg.1690]    [Pg.172]    [Pg.5]    [Pg.6]    [Pg.510]    [Pg.1732]    [Pg.1736]    [Pg.71]    [Pg.22]    [Pg.282]    [Pg.200]    [Pg.216]    [Pg.197]    [Pg.225]    [Pg.311]    [Pg.113]    [Pg.120]    [Pg.160]    [Pg.371]   
See also in sourсe #XX -- [ Pg.892 ]




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