Iododeoxyuridine , labeling

While the effects of internally deposited radionuclides are attributable in most instances to the type and energy of the radiations they emit, their transmutation on decay has also been implicated in certain circumstances, e.g., the severe mutagenicity and lethality caused by decay of iodine-125 in 5-iododeoxyuridine-labelled DNA is attributed in part to rupture of the uracil ring following transmutation of the iodine (Stocklin, 1979). 

F2. Fidler, I. J., Metastasis Quantitative analysis of distribution and fate of tumor cell emboli labelled with 125I-5-iododeoxyuridine. J. Natl. Cancer Inst. (U.S.) 45, 773-782 (1970). 

Bums, K.A., Kuan, C.Y. (2005) Low doses of bromo- and iododeoxyuridine produce nearsaturation labeling of adult proliferative populations in the dentate gyms. Eur J Neurosci 21, 803-7. 

I-labeled nucleic acid precursors (e.g., 5 -iododeoxyuridine, a thymidine analog) in... 

Starting from 5-iododeoxyuridine, Hurley and Tor synthesized 1,10-phenanthroline-labeled nucleosides, containing a [(bipy)2M(3-ethynyl-l,10-phenanthroline)] (M=Ru, Os) moiety covalently attached to the 5 position of the 2 -deoxyuridine (Scheme 5). Both complexes exhibited a fully reversible electrochemistry with 1/2=0.993 V for Ru + + and 0.560 V for (vs. Ag/Ag+, in... 

Nucleosides - Although 5-iododeoxyuridine (Ldoxuridine lUM "Stoxil" "Herplex ) has proven successful in the treatment of herpetic keratitis of the eyes, it has been less successful in the treatment of herpes simplex encephalitis. Using labelled lUDR it was found that insignificant amounts of lUMt entered the brain after IV injection (67). 

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