Intraocular lesions

Uveal Melanoma. Charged particle beams and, in particular, protons are ideal for treating intraocular lesions since they can be made to deposit their absorbed dose in the target volume, while significantly limiting the irradiation of the noninvolved ocular and orbital structures (Fig. 16). 

Or signs of the intraocular lesions due to the penetration of the chemical into the eye. We shall remind that the penetration of a chemical into the eye is very fast and happens within the first minute after projection (See Sect. 5.16 and Fig. 5.12). 

Recently, a new indication appeared detection of malignant melanoma of the uveal tract. I-IMP shows accumulation in the intraocular lesion, while benign lesions show no site of fixation (Goto, 2004 Kato et al., 2006). 

In a second experiment, Ayers and Stahl studied the effects of discharging a CS pen-gun cartridge into a rabbit eye at a distance of 20 cm. At that distance, the wad caused less damage than the blast and the particles of CS. Only three of 10 animals suffered severe eye lesions, which appeared to combine mechanical damage (lacerations) from the wad and conjunctivitis, intraocular hemorrhage, keratitis, and corneal edema probably from the blast and CS particles driven into the eye. The other animals showed only mild conjunctivitis, which cleared after 3 d. 

Its action on the comeal transparency only visible in case of pathology, the part played by the intraocular pressure is to be considered separately. Indeed, the big increase of the intraocular pressure may cause a stromal edema and this might happen after a chemical eye bum with lesion at the level of the trabeculum. 

Glaucoma is a type of optic neuropathy associated with characteristic optic disk damage, which may result in certain visual field loss patterns, at least partly in response to suboptimal intraocular pressure. There are three representative ocular lesions containing glycosaminoglycans, namely the aqueous humor, trabecular meshwork, and optic nerve head/lamina cribrosa, which are involved in glaucoma. 

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