Intranasal drug delivery peptides

Maggio, E.T. 2005. Recent developments in intranasal drug delivery technology are creating new vistas for peptide and protein therapeutics. Drug Deliv Comp Report, Spring/Summer 34 37. 

Numerous papers have reported on the possible utility of nasal administration of a variety of compounds, including peptide and protein drugs. However, only a small number of products are of clinical use for intranasal systemic delivery, as mentioned earlier. Especially, most peptide and protein drugs show insufficient nasal bioavailability, which may be one of the reasons for difficulties in development. To improve the nasal absorption of peptide and protein drugs, several strategies classified as follows have been intensively investigated and discussed during the last two decades ... 

Pontiroli, A. E., Alberetto, M., Calderara, A., Pajetta, E., and Pozza, G., 1986, Metabolic effects of intranasally administered insulin and glucagon in man, in Delivery Systemsfor Peptide drugs (S. S. Davis, L. Ilium, and E. Tomlinson, eds.). Plenum Press, New York, pp. 243-248. 

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