Treatment of Intoxication

Treatment of acute PCP intoxication includes efforts to decrease gastrointestinal absorption of the drug (e.g., by activated charcoal) and to increase renal 

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Humans tolerate fairly large oral doses of copper without harmful effects, and it is used in various therapies (66). Copper sulfate is a powerful emetic and has been used clinically in the treatment of intoxications. 

Symptoms and Treatment of Intoxication With Other Tryptamine-Related Compounds... 

Fusek, J. and J. Bajgar. "Antidotal Treatment of Intoxication with New Nerve Agent G V." In Proceedings of the CB Medical Treatment Symposium an Exploration of Present Capabilities and Future Requirements for Chemical and Biological Medical Treatment. Edgewood, MD Battelle Memorial Institute, 1994, 6.6—6.8. 

C. Dishovsky et al. (eds.), Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack, 3-11. 

Treatment of intoxication of organophosphorons componnds inclndes artificial respiration, administration of atropine—an antagonist of mnscarinic receptors, and administration of pralidoxime, which is a cholinesterase reactivator. 

Hopff and Waser have listed mechanisms whereby reactivators of Inhibited cholinesterase could be harmful to persons to whom they are administered In treatment of intoxication by anticholinesterase compounds. The following is a slightly modified version of their list ... 

Osmotically acting diuretic agents. These are applied in the treatment of intoxication in order to increase the urine volume and accelerate elimination of the poison ( forced diuresis ). The classical example is mannitol. This sugar is quite similar to glucose in structure but does not get metabolized nor reabsorbed from the primary glomerular filtrate in the kidneys. 

Blye E, Lorch J, Cortell S. Extracorporeal therapy in the treatment of intoxication. Am J Kidney Dis 1984 3 321-38. 

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