Nucleosides, antiviral

Systematic studies on the influence of mobile-phase additives and the pH of the mobile phase have been reported frequently, e.g., for tetracyclines [100], nucleoside antiviral agents [101], and a variety of basic and acidic dmgs [102]. 

A.M. Kamel, P.R. Brown, B. Munson, Effects of mobile-phase additives, solution pH, ionization constant, and analyte concentration on the sensitivities and ESI mass spectra of nucleoside antiviral agents. Anal. Chem., 71 (1999) 5481. 

Vibramycin doxycycline. vidarabine [ban. inn. jan. usan) (adenine arabinoside Ara-A Vira-A ) is a purine nucleoside ANTIVIRAL isolated from the marine gorgonian Evnicella cavoUni and Streptomyces spp. Clinically, it may be used to treat herpes simplex and vaccinia infections. 

There are abont 200 types of cells in human tissues and all their plasma membranes and the membranes of their organelles contain transporters. The drug transporters at the organelles may well become most important in the future. This was recently documented during a dramatic Phase II trial in which the nucleoside antiviral fialuridine (FIAU) caused the death of subjects as a result of severe toxicity... 

Wang LH, Blum MR, Hui J, Hulett L, Chittick GE, Rousseau F. Lack of significant pharmacokinetic interactions between emtricitabine and oAer nucleoside antivirals in healthy volunteers, Intersci Corf Antimicrob Agents Chemodier (2001) 41,18. 

Analogues 249 (X = H, OH) of UDP-GlcNAc have been prepared as potential inhibitors of chitin synthetases. The synthetic route involved a C-allyl derivative of GlcNAc, which was elaborated by ozonolysis, Wittig reaction and coupling with the nucleoside, followed by hydrogenation or hydroxylation as appropriate. The corresponding amides were also prepared from 5 -amino-5 -deoxyuridine. Lipophilic amino acid methyl esters and methylamides have been coupled to 0-5 of AZT by carbamate links. The products showed anti-HIV activity, but this was not due to carbamate hydrolysis or to direct inhibition of reverse transcriptase, and the mechanism of action may be one not previously observed with nucleoside antivirals. ... 

Ray AS, Hostetler KY (2011) Application of kinase bypass strategies to nucleoside antivirals. Antiviral Res 92 277-291... 

Hurwitz SJ, Schinazi RF (2013) Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors. Curr Opin HIV AIDS 8 556-564... 

General - A comprehensive, critical review (228 refs.) has covered developments over the last ten years in the chromatographic analysis of carbohydrates by g.c., h.p.l.c., t.l.c., and supercritical fluid chromatographic methods. T.l.c., h.p.l.c., and g.c.-m.s. methods for analysis of cardiac glycosides, and h.p.l.c. and g.c. methods for the analysis of nucleoside antiviral drugs, have also been reviewed. 

P. Van Roey and R.F. Schinazi, The crystal and molecular structure of 3 -fluoro-3 -deoxythymidine, a potent anti-HTV-1 nucleoside. Antiviral Chem. Chemother., 1 93 (1990). 

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