Intestinal P-glycoprotein

K Westphal, A Weinbrenner, T Giessmann, M Stuhr, G Franke, M Zschiesche, R Oertel, B Terhaag, HK Kroemer, W Siegmund. Oral bioavailability of digoxin is enhanced by talinolol evidence for involvement of intestinal p-glycoprotein. Clin Pharmacol Ther 68 6-12, 2000. 

L. Z. Benet. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4, /. 

B. FI., Wu, X., Reyner, E. L. et al., Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J. Clin. Pharmacol. 

Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother. Pharmacol. 1995,... 

Hebert, M. F., Contributions of hepatic and intestinal P-glycoprotein to cyclosporine and tacrolimus oral drug delivery, Adv. Drug. Del. Rev. 

Shen Q, Lin Y, Handa T, Doi M, Sugie M, Wakayama K, Okada N, Fujita T, Yamamoto A (2006) Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm 313 49-56. 

D. Durr, B. Stieger, G. A. Kullak-Ublick, K. M. Rentsch, H. C. Steinert, P. J. Meier, and K. Fattinger. St John s Wort induces intestinal P-glycoprotein/MDRl and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 68 598-604 (2000). 

Cummins, C.L., Jacobsen, W., and Benet, L.Z., Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4,. Pharmacol. Exp. Ther., 300,1036, 2002. 

Lown KS, Mayo RR, Leichtman AB, et al. Role of intestinal P-glycoprotein (mdrl) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 1997 62 248-260. 

Other mechanisms of interaction have also been reported, such as altered activity of other enzymes within the CYP450 family (14—17). Moreover, GFJ may also inhibit the intestinal P-glycoprotein (P-gp)-mediated efflux transport of drugs such as cyclosporine to increase its oral bioavailability (18-21). GFJ and other fruit juices have recently been shown to be potent in vitro inhibitors of a number of organic anion-transporting polypeptides (OATPs) (22,23). 

Parker RB, Yates CR, Soberman JE, Laizure SC. Effects of grapefruit juice on intestinal P-glycoprotein evaluation using digoxin in humans. Pharmacotherapy 2003 23(8) 979-987. 

Neudeck BL, Foster DR, Li LY, et al. The effects of thermal injury on transcellular permeability and intestinal P glycoprotein in rats. Bums. 2003 29 803-809. 

Adachi Y, Suzuki H, Sugiyama Y. Quantitative evaluation of the function of small intestinal P-glycoprotein comparative studies between in situ and in vitro. Pharm Res 2003 20 1163-1169. 

Greiner B, Eichelbaum M, Fritz P, et al. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 1999 104 147-153. 

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