Interstitial laser therapy

Epidemiology of Breast Cancer 221 Interstitial Laser Therapy (ILT) 222 Radiofrequency Ablation (RFA) 223 High-Intensity Focused Ultrasound (HIFU) 224... 

Fig. 7.2.1a-e. Interstitial laser therapy, a The tip of the laser fiber is visualized as a tiny ear-shaped loss of signal black arrows), b On the subtracted phase images a small hypointense zone of increased temperature can be delineated after 120 s of laser treatment (3 W, 600 s). c It is expanding after 360 s and d furthermore after 600 s white arrows). eThe follow-up examination 1 week later shows an anlog hypointense zone indicating coagulation necrosis... 

Interstitial laser therapy (ILT) A form of thermal ablation using a laser as the heat source. 

Since the first description of interstitial tumor thermal ablation using laser therapy by Sown in 1983, experimental studies have shown that a reproducible... 

Unresectable and chemorefractory malignant tumors in the liver are a major cause of death in solid tumors. Potentially curative surgery is uncommon for these patients. A number of liver-directed therapies are now available and are making important contributions to quality of life, prolonged time to liver progression, and overall survival. Limited surgery involving laparoscopy and percutaneous access approaches enables local tumor resection, cryotherapy, laser-induced interstitial thermotherapy, and radiofrequency ablation. 

Laser-induced interstitial thermotherapy represents a minimally invasive therapy, where the cancerous tissue is irradiated by laser light guided through an optical fiber. Planning the operation anticipates the knowledge of the absorption and scattering properties of cancerous tissue compared to healthy tissue. Several optical and computational techniques have been developed that can... 

S.F. Purkiss, R. Dean, J.T. Allardice, M. Grahn, N.S. Williams An interstitial light delivery system for photodynamic therapy within the liver. Lasers Med. Sci. 8, 253 (1993)... 

All of the percutaneous techniques are limited by the size and number of the lesions (up to three lesions each measuring up to 4 cm) as well as their location. Subdiaphragmatic lesions may be percutaneously inaccessible, and lesions close to large vascular structures respond poorly to thermal ablation techniques (RFA, MCT, Cryo, and LIPC). On the contrary, intra-arterial techniques are not limited by the number, size, or location of the lesions rather by the hepatic function reserve, as shown in Table 10.2. TACE, trans-arterial chemo-embolization TARE, trans-arterial radio-embolization MCT, microwave coagulation therapy RFA, radio frequency ablation LIPC, laser interstitial photocoagulation Cryo, cryo-ablation PEI, percutaneous ethanol injection PAAI, percutaneous acetic acid injection PCI, percutaneous chemotherapy injection... 

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