Interpretation of Changes in Drug Disposition and Interspecies Scaling

Interpretation of Changes in Drug Disposition and Interspecies Scaling 

Disposition is the term used to describe the simultaneous effects of distribution and elimination, that is, the processes that occur subsequent to the absorption of a drug into the systemic circulation. The disposition of a drug is 

In the presence of Escherichia coli endotoxin-induced fever in dogs and etio-cholanolone-stimulated fever in human beings, the serum concentrations of gentamicin are lower than in the afebrile state (Fig. 3.1) (Pennington et al., 1975). This could be attributed to increased extravascular distribution of gentamicin, although renal clearance and the half-life of the antibiotic were not significantly 

The effect of experimentally induced bacterial infections, all of which have in common the presence of fever, on the disposition of various antimicrobial agents in pigs is presented in Table 3.1. In the infected pigs, the apparent volume of distribution of penicillin G, ampicillin and, to a lesser extent, trimethoprim is increased, of enrofloxacin and sulphonamides remains unchanged, and of oxytetracycline is decreased. The systemic clearance of penicillin G, ampicillin and trimethoprim is increased, of sulphamethoxazole and sulphadimethoxine remains unchanged, and of sulphadimidine, 

Antimicrobial agent Healthy Infected Level of significance 

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