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Disposition of drug

Doran, A., Obach, R. S., Smith, B. J., et al. (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system evaluation using the MDRIA/IB knockout mouse model. Drug Metab. Dispos. 33, 165-174. [Pg.61]

Genotypic Differences in CYP2C19 May Modulate Disposition of Drug Therapy for H. pylori Infection and Cure Rates... [Pg.388]

Achievement of a desired drug concentration-time profile. Although physiological processes govern the disposition of drug in the body, several pharmacokinetic parameters are still useful for evaluating drugs as candidates for controlled release delivery systems. In addition to potency, the pharmacokinetic parameters systemic clearance Cl, volume of... [Pg.30]

The elderly represent a growing proportion of the total population, and it is necessary to appreciate the age-associated physiological changes that occur in these patients and their effects on the disposition of drugs. [Pg.152]

Factors affecting metabolism and disposition of drugs or xenobiotics in vivo have been amply described elsewhere (Timbrell, 1991). They may be divided into biological factors and molecular factors. [Pg.225]

Due to its compartmental nature, the CAT model can be easily coupled with the disposition of drug in the body using classical pharmacokinetic modeling. In this respect the CAT model has been used to interpret the saturable small-intestinal absorption of cefatrizine in humans [175]. [Pg.124]

L Lemberger and A Rubin, Physiological Disposition of Drugs, Chap 5, Spectrum Publications, New York (1976)... [Pg.103]

Lung cell cultures can provide mechanistic insights but they do not represent the complexity in the delivery and disposition of drugs in the human respiratory tract. Perfused lung organ studies provide the next level in complexity. Various animal models have been used with the view to predict quantitatively absorption of peptides and proteins from the human lungs. However, due to the major differences in the anatomy and physiology of respiration in primates, the predictive power of these models is quite limited as evidenced by the data in Fig. 2. (Animal models are, of course, essential in the assessment of safety and they can provide valuable mechanistic information.)... [Pg.2735]

The fundamental principle of toxicology is the concept that the sixteenth century physician Paracelsus articulated in the 1500s sola dosis facit venenum or the dose makes the poison . The modem version of this observation is the dose-response relationship, which is experimentally and theoretically supported through pharmacokinetic and pharmacodynamic experimentation. Pharmacokinetics is concerned with the study of the time course of the disposition of drugs, specifically absorption, distribution, metabolism and elimination, often referred to as ADME. In non-technical terms it can be thought of as what the body does to the chemical. An understanding of the pharmacokinetic (in the case of dmgs) or toxicokinetic (all chemicals) profile is critical to estimate the... [Pg.128]

Poola et al studied the renal excretion of pentamidine in the isolated perfused rat kidney, which is an established model to study the renal disposition of drugs and that correlates with in vivo disposition. The data showed that a combination of filtration, active secretion and passive reabsortion are involved in the renal disposition of pentamidine [150]. [Pg.363]

Verbeeck, R.K. (1982) Glucuronidation and disposition of drug glucuronides in patients with renal failure. A review. Drug Metabolism and Disposition, 10, 87-89. [Pg.135]

The physiological features of the neonatal period that influence the bioavailability and disposition of drugs should be considered when selecting the route of administration and the dosage interval. An appreciation of species differences in the rate at which age-related physiological variables mature, and... [Pg.263]

L. Lemberger and A. Rubin, "Physiologic Disposition of Drugs of Abuse", Spectrum Publications, Holliswood, N. Y., 1976. [Pg.207]


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See also in sourсe #XX -- [ Pg.191 ]




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