Semilente insulin

Semilente insulin is a suspension of amorphous insulin zinc. The onset is 1-3 hours after subcutaneous administration, reaches maximum effect in 5-10 hours and the effect lasts 10-16 hours. Isophane insulin (NPH Neutral solution. Protamine, Hagedorn s laboratoiy insulin) is an intermediate-acting preparation prepared with protamine. The maximum effect is reached in 4-12 hours and lasts 8-26 hours. Patients using these preparations who present for cardiac surgery are at increased risk for anaphylactic reactions to protamine. Ultralente insulin is a long-acting preparation formed with zinc rather than protamine. Zinc retards the release of insulin and these preparations have a duration of up to 36 hours. Protamine zinc insulin, which contains both protamine and zinc, has a duration of 28-36 hours. 

Ultralente or semilente insulin is used to eliminate nocturnal and early-morning hyperglycemia. Complications of Insulin Therapy... 

Semilente insulin suspension This insulin is an amorphous precipitate of insulin with zinc ion in acetate buffer that is not suitable for intravenous administration. Its onset of actions and peak effect are rapid, but somewhat slower than for regular insulin. 

Lente insulin This insulin is a mixture of 30% semilente insulin (prompt acting) and 70% ultralente insulin (prolonged acting). 

Morning injection of semilente insulin and evening injection of lente insulin... 

---