Interleukin Genetics

Thanks to Ken Komman and John Rogus, Interleukin Genetics, Waltham, Massachusetts and Haeri Roh-Schmidt, David Krempin, Audra J. Davies, and Kerry Grann, Nutrilite Health Institute, Buena Park, California. 

The inflammatory response in UC is propagated by atypical type 2 helper T cells that produce proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF).7 As discussed previously, a genetic predisposition to UC may partially explain the development of excessive colonic and rectal inflammation. The finding of positive perinuclear antineutrophil cytoplasmic antibodies (pANCA) in association with the human leukocyte antigen (HLA)-DR2 allele in a large percentage of patients with UC supports this theory.4,12... 

Takamatsu, M. et al., Genetic polymorphisms of interleukin-1 beta in association with the development of alcoholic liver disease in Japanese patients, Am. J. Gastroenterol., 95 (5), 1305, 2000. 

Rebeck, G. W., Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer s disease, Neurosci. Lett., 293, 75, 2000. 

Magnuson, N.S., Linzmaier, P.M., Reeves, R., An, G., HayGlass, K., and Lee, J.M. (1998). Secretion of biologically active human interleukin-2 and inter-leukin-4 from genetically modified tobacco cells in suspension culture. Protein Exp. Purif. 13(1) 45-52. 

Komman KS. Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging. Am J Clin Nutr 2006, 83(2) 475S-483S. 

Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C et al. Single nucleotide polymorphisms in the human interleukin-IB gene affect transcription according to haplotype context. Hum Mol Genet 2006, 15(4) 519-529. 

L8. Lazarus, M., Hajeer, A. H., Turner, D., Sinnott, P., Worthighton, J., etal., Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J. Rheumatol. 24, 2314-2317 (1997). 

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