Interferons meta-analysis

Efficacy Patients with relapsing remitting MS A meta-analysis of all beta interferons determined that treated patients were 27% and 19% less likely to have a relapse during the first and second years of treatment, respectively, than those who had... [Pg.436]

Wheatley, K. et al., Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit A meta-analysis of the randomised trials, Cancer Treat. Rev, 29, 241, 2003. [Pg.166]

C. D. Naylor, A.S. Detsky, and 1. Heathcote, Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B a meta-analysis. Ann Intern Med, 1993.119 312-23. [Pg.184]

Poynard, T., V. Leroy, M. Cohard, et al., Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C effects of dose and duration. Hepatology, 1996. 24 778. [Pg.185]

Interferon alfa versus chemotherapy for chronic myeloid leukemia a meta-analysis of seven randomized trials Chronic Myeloid Leukemia Trialists Collaborative Group. J Natl Cancer Inst 1997 89 1616-1620. [Pg.145]

A recent meta-analysis of clinical trials in patients with chronic HBV infection showed that treatment with interferon alfa is associated with a higher incidence of hepatitis e antigen (HBeAg) seroconversion and undetectable HBV DNA levels than placebo. The addition of the pegylated moiety results in further increases in the proportion of patients with HBeAg seroconversion ( 30%) and a decline by approximately 4 log copies/mL (99.99%) in HBV DNA after 1 year. [Pg.1084]

Although isolated reports of psychotic delusional symptoms and depression continue to be published (404), recent controlled trials or longitudinal studies have not provided evidence of an increase in depression scores or in the rate of depression in patients treated with interferon beta (SEDA-27, 389). In a meta-analysis of seven trials in 1215 patients with relapsing remitting multiple sclerosis, the incidence of depression was 16% and did not differ between interferon-beta and controls, but the scales used to assess depression were specified in only three trials (405). Using a public reimbursement database for multiple sclerosis, the prevalence and incidence of depression and depression scores were not different in 163 patients treated with interferon beta or glatiramer, but the study was poorly controlled for potential biases (406). Overall, the current data suggest that interferon-beta is not substantially associated with depression. [Pg.677]

Malaguarnera, M., Restuccia, S., Receputo, G., Giugno, L, Pistone, G., Trovato, B.A. The efficacy of interferon alpha in chronic hepatitis B a review and meta-analysis. Curr. Ther. Res. 1996 57 646- 2... [Pg.713]

Interferon alfa, in combination with ribavirin, is currently first-line therapy for patients with chronic hepatitis C and compensated liver disease, and its use has been extensively reviewed (6). A meta-analysis of trials in patients who were... [Pg.1793]

Druyts E, Thorlund K, Wu P, Kanters S, Yaya S, Cooper CL, et al. Efficacy and safety of pegylated interferon alfa-2a or alfa-2b plus ribavirin for the treatment of chronic hepatitis in children and adolescents a systematic review and meta-analysis. CUn Infect Dis... [Pg.584]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...