Interferons, and the Acute-Phase Response

Cytokines, Interferons, and the Acute-Phase Response System... 

Morimoto, A., Murakami, M., Takada, M., Teshirogti, S., Watanabe, T. (1987). Fever and the acute phase response induced in rabbits by human recombinant interferon. J. Physiol. 391, 209-218. 

The body responds in many ways to infection, injury, or cancer. These include the secretion of cytokines, interferons, and proteins of the acute phase response. These proteins, many of which are quite... 

Chen JQ, Strom A, Gustafsson JA, Morgan ET. Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol Pharmacol 1995 47 940-7. 

Numerous biochemical markers of neuroinflammation have also been found in ALS tissue. The families of compounds include cytokines, chemokines, complement proteins, prostaglandins, interleukins, interferons, integrins, acute phase reactants, apolipoproteins, and (Table 27.1). Many of these biochemical markers have also been found in Alzheimer s disease tissues, suggesting that the inflammatory response in the two conditions may be similar (Eikelenboom and van Gool 2004). 

G4. Gauldie, J., Richards, C., Hamish, D., and Baumann, H. Interferon beta-2 is identical to monocyte HSF and regulates the full acute phase protein response in liver cells. In Monokines and Other Non-lymphatic Cytokines (M. C. Powanda, J. J. Oppenheim, M. J. Klugger, and C. A. Dinarello, eds.), pp. 15-20. Liss, New York, 1988. 

Reticulose. Reticulose is a peptide-nucleic acid solution in which ribonucleic acid is combined with short-chain peptides. Recently, reticulose has been described as an immune system modulator, and early clinical studies have shown that reticulose has an ability to rapidly inhibit the course of a variety of viral diseases, particularly in the acute stage. However, it has also been reported to be effective in sub-acute and chronic phases of certain infections and has exhibited no reported side effects in over 20 years of use. Retieulose appears to act by alteration of the host cell response to viral replication. It seems to stimulate the immune system via increases in endogenous interferon and increases in lymphocyte production. In clinical trials with patients infected with hepatitis A or B viruses, treatment with reticulose demonstrated positive results in that serum bilirubin levels reached normal levels and white blood eell count showed significant increases, indicating stimulation of the immune system (190). 

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