Role for Interferons

It appears that the mechanisms of CXCL9- and CXCLlO-mediated viral clearance involve NK cells and IFNs. The increases in lymphoid cell numbers at foci of infection contribute to virus clearance through the action of cytolysis and IFN secretion. Through the induction 

Saederup N, Lin YC, Dairaghi DJ et al. Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the host. Proc Natl Acad Sci USA 1999 96 10881-10886. 

Moore JP, Trkola A, Dragic T. Co-receptors for HIV-1 entry. Curr Opin Immunol 1997 9 551 562. 

Karupiah G, Fredrickson TN, Holmes KL et al. Importance of interferons in recovery from mousepox. J Virol 1993 67 4214-4226. 

Ruby J, Ramshaw I. The antiviral activity of immune CD8+ T cells is dependent on interferon-gamma. Lymphokine Cytokine Res 1991 10 353-358. 

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Take Y, SimsTN, Urmson J, Halloran PF Central role for interferon-gamma receptor in the regulation of renal MHC expression, J Am Soc Nephrol 2000,11 250-261... 

Flynn JL, Chan J, TiieboldKJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to AfycoAocteriujM tuberculosis infection. J Exp Med 1993 178(6) 2249-2254. 

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