Interferon pharmacology

Rosenblum, M.G., Unger, B.W., Gutterman, J.U., Hersh, E.M., David, G.S., and Frincke, J.M. (1985) Modification of human leukocyte interferon pharmacology with a mono clonal antibody. Cancer Research, 45, 2421 2424. 

Rosenblum MG, Unger BW, Gntterman JU, Hersh EM, David GS, Frincke JM. Modification of human leukocyte interferon pharmacology with a monoclonal antibody. 

Arnaud P (2002). The interferons Pharmacology, mechanism of action, tolerance and side effects. Rev. Med. Inter. 23 (suppl 4) 449s-458s. 

Pharmacology and Mechanism of Action The mechanism of action of beta interferons is complex and not completely understood. The following properties are thought to be important to the mechanism of action ... 

Mantovani, A. 2000. Pharmacology of Cytokines. Oxford University Press Pieters, T. 2005. Interferon. Routledge, London, UK. 

Foster, G. 2004. PEGylated interferons chemical and clinical differences. Alimentary Pharmacology and Therapeutics 20(8), 825-830. 

Pharmacology Interferons bind to specific receptors on the cell surface, initiating intracellular signaling via a complex cascade of protein-protein interactions and... 

Pharmacology The biological activity of peginterferon alfa-2b is derived from its interferon alfa-2b moiety. Interferons exert their cellular activities by binding to specific membrane receptors on the cell surface and initiate a complex sequence of intracellular events. 

Pharmacology Interferon beta-1 a and beta-lb have antiviral, antiproliferative, and immunoregulatory activities. The mechanisms by which they exert their actions in MS are not clearly understood. 

Clinical pharmacology The mechanism by which interferon alfa-2a recombinant, or any other interferon, exerts antitumor or antiviral activity is not clearly... 

The possibility that interferons can be used as pharmacologic agents has aroused a great deal of interest. Recombinant DNA techniques and cell tissue cultures have been used to produce sufficient quantities of interferons for clinical drug trials. The rationale is that exogenously administered interferons will produce antiviral and other beneficial effects in healthy cells in a manner similar to their endogenously produced counterparts. Some of the pertinent aspects of interferon action and clinical applications are presented below. 

Interferon A member of the group of proteins that exert a number of physiologic and pharmacologic effects, including antiviral and antineoplastic activity. 

The interferon induction with similar pharmacological effects such as immunization is also connected with an activation of these cells. 

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