Interface hepatitis

A 67-year-old man developed Stevens-Johnson syndrome after taking glibenclamide 20 mg/day for 4 weeks, having previously used insulin. He died from hemorrhagic bronchopneumonia. Post mortem examination also showed features of granulomatous arteritis and cholestatic interface hepatitis, suggestive of a hypersensitivity reaction (129). 

Periportal inflammation Periportal hepatitis is characterized by penetration of the limiting plate. The border between the portal field and the lobule can appear irregular sometimes it assumes the shape of a maple leaf In this periportal zone (i.e. zone 1), piecemeal necroses may develop. They are, however, not true necroses , but apoptoses. Today, periportal inflammation with piecemeal necrosis is termed interface hepatitis. This condition is not always accompanied by piecemeal necrosis the inflammatory infiltrate can also enter the lobule without causing liver cell necroses. The composition of the inflammatory infiltrates is similar to that in the portal fields. Periportal infiammation contributes to the grading of chronic hepatitis, (l)... 

Relapse Reactivation is often associated with the presence of wildtype HBV (80-85%) or the occurrence of precore mutants (15-20%). This event (increase of transaminases, evidence of replication markers such as HBeAg and HBV DNA, positive IgM anti-HBC, pronounced interface hepatitis) develops in 15-20% of cases 1-3 years after IFNa therapy has been stopped. In such cases the question then arises of whether to apply lamivudine. This antiviral agent is administered in cases with an unfavourable constellation or contraindication regarding IFNa, or if the patient refuses IFN. 

Viral infections may lead to hepatitis, which may become chronic, eventually leading to cirrhosis. In these infections, there is usually some degree of inflammatory mononuclear infiltrate in portal tracts, interface hepatitis, and lobular inflammation however, since the inflammation is variable and does not always parallel... 

Liver Approximately 1 in 10 cases of autoimmune hepatitis is triggered by drugs [80 ]. After 2 months and six doses of adalimumab, a 52-year-old woman developed malaise and liver damage diagnosed as autoimmune hepatitis on fhe basis of elevations of hepatobiliary enzymes, positive conversion of antinuclear antibodies, high IgG levels and liver biopsy which showed portal lymphoplasmacytic inflammation, periportal interface hepatitis and lobular necroinflammatory changes [80 ]. 

Multidimensional LC has also been used to determine ursodeoxycholic acid and its conjugates in serum (14). These compounds are used in the treatment of cholesterol gallstones, hepatitis and bilary cirrhosis. These authors employed a traditional (10 X 4 mm) pre-column and a micro-bore (35 X 2 mm) analytical column that were interfaced by using a six-port switching valve. 

After experimental distal occlusion of the hepatic arteries in rats necrotic areas were observed. However, these necroses were bypassed by vessels similar to the capillarized sinusoids observed in the cirrhotic liver in humans. These vessels acted as sinusoidal shunts in the embolized territories (Tancredi et al. 1999) and were the reason for the resulting viable tumor cells after TACE treatment (Fan et al. 1998). Based on these results, the antitumor effect of TACE showed a mean partial response rate of 26.9%, while the mean complete response rate was only 6% (Camma et al. 2002). To improve the therapeutic results for large liver tumors and increase the survival rates, it is still necessary to eliminate the remaining viable tumor cells at the tumor-host interface. 

Tang, D. P, R. Yuan, Y. Q.Chai, X. Zhong, Y. Liu, and J. Y. Dai, 2006. Electrochemical detection of hepatitis B surface antigen using colloidal gold nanoparticles modified by a sol-gel network interface. Clin Biochem 39 309-14. 

Newly synthesized plasma cholesterol, predominantly of hepatic origin, rapidly achieves equilibrium in vivo with the cholesterol in the stroma of the erythrocyte. This same equilibrium between the plasma free cholesterol and that of the red cell has been demonstrated in vitro, 50% equilibration took place in 1 hour. Ester cholesterol did not participate in this exchange. The equilibration probably is brought about by an exchange reaction at the several interfaces. An exchange of a similar nature could account for the relatively uniform distribution of isotopic cholesterol in liver, plasma, and red cells after acetate-C administration and for the rapidity with which this uniformity is achieved. 

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