Drug interactions anticoagulants

O Reilly, R. A., Studies on the coumarin anticoagulant drugs interaction of human plasma albumin and warfarin sodium. J. Clin. Invest. 46, 829-837 (1967). 

Andrus MR. Oral anticoagulant drug interactions with statins case report of fluvastatin and review of the literature. Pharmacotherapy 2004 24(2) 285-90. 

Screen the patient s pharmacy profile for potential drug-drug interactions with anticoagulation therapy... 

Drug interactions with diflusinol include acetaminophen anticoagulants, oral hydrochlorothiazide indomethacin sulindac. 

The following drug interactions were reported for metronidazole, a chemically related nitroimidazole. Therefore, these drug interactions may occur with tinidazole. Drugs that may affect tinidazole include cholestyramine, CYP3A4 inducers and inhibitors and oxytetracycline. Drugs that may be affected by tinidazole include alcohols, anticoagulants, cyclosporine, tacrolimus, disulfiram, fluorouracil, hydantoins, and lithium. 

As it inhibits microsomal cytochrome P450 cimetidine has a high potential for drug interactions not shared by the other H2 receptor antagonists. The oxidative metabolism of agents such as anticoagulants, most antiepileptics, some beta-blockers, warfarin, theophylline and many hypnotics, neuroleptics and antidepressants may be reduced, leading to increased effects. 

TABLE 22.1 Drug Interactions Involving Oral Anticoagulants... 

Significant drug-drug interactions are those that potentiate the effects of other agents and require dosage modification. These include certain anticoagulants, hypoglycemic sulfonylureas, and hydantoin anticonvulsants. 

The most important drug interaction caused by displacement from plasma proteins occur with coumarin anticoagulants. Phenylbutazone displaces warfarin from its... 

Drug interactions Concurrent administration of ReoPro with oral anticoagulants is contraindicated. Limited experience with the concurrent use of ReoPro and low molecular weight dextran during a PTCA procedure has also shown an increased risk of a major bleeding episode. Concurrent administration of ReoPro and heparin may also increase the risk of bleeding, but ReoPro is intended for use with aspirin and heparin and has only been studied in that setting. ReoPro has... 

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