Interaction inter-domain

Fig. 4.4. Representative domains and interac- acting proteins are listed directly below the tions of members of RING finger families. In various domains. RING finger indicated by RF. (A-D) underlines indicate areas of interactions CARD domain not found in XIAP. with other proteins. In (E) representative inter-...

Further consequences of the yield stress [i.e., the plug flow] are (i) a drastic reduction of the extrudate swell, B = d/d (d is diameter of the extrudate, d that of the die) [see, e.g., Crowson and FoUces, 1980 Utracki et al, 1984], and (ii) significant increase of the entrance-exit pressure drop, Pg (also known as Bagley correction). For single-phase fluids, these parameters have been related to elasticity by molecular mechanisms [Tanner, 1970 Cogswell, 1972 Laun and Schuch, 1989]. However, in multiphase systems, both B and P depend primarily on the inter-domain interactions and morphology, not on deformation of the macromolecular coils. Thus, in multiphase systems [i.e., blends, filled systems, or composites], only direct measures of elasticity, such as that of Nj, or G should be used. It is customary to plot the measure of the elastic component versus that of the shear components, viz., vs. 

Although direct evidence for inter-domain interactions have not been reported for vCaM, a number of observations have provided indirect support for this, suggesting that vCaM may also assume a collapsed state (Zhang, et al. 1995, Ohki et al. 1997, Shea et al.l996). The Inability to detect such a state indicates that this form must have a shorter lifeUme and/or has a much lower population in vCaM than in the yeast counterpart. 

The dependence holds in steady-state as well as dynamic flowin shear or elongation, it is easy to use, and the extracted parameters calculated from equation fitting to experimental data agree with the directiy measured values. The magnitude of ay increases with aspect ratio, p, their rigidity, and concentration. Some consequences of Oy are the plug flow [77,78], reduction of the extrudate swell. Be [7,79], and increase of the entrance-exit pressure drop, Pe [80, 81]. In multiphase systems both Be and Pe depend mainly on the inter-domain interactions and morphology. 

For spin-f nuclei, dipolar interactions may be modulated by intramolecular (DF, reorientation etc.) and/or intermolecular (TD) processes. In general, the intra- and inter-molecular processes can produce quite different Tj frequency dispersion curves. In practice, NMR field cycling experiments are often needed to extend the frequency domain from those employed in conventional spectrometers to a lower frequency range (i.e., the kHz regime) for unambiguous separation (and identification) of different relaxation mechanisms. The proton spin relaxation by anisotropic TD in various mesophases has been considered by Zumer and Vilfan.131 133,159 In the nematic phase, Zumer and Vilfan found the following expression for T ... 

The c-Cbl-E2-ZAP70 peptide complex adapts a compact structure with multiple inter- and intra-molecular interfaces (Figure 7.2) [49]. The RING domain is anchored on the TKB domain through extensive interactions with the 4H bundle, whde the linker forms an ordered loop and an a-helix, which packs closely with... 

---