Integrins ligand interactions with

A family of transmembrane proteins referred to as integrins is capable of interactions with extracellular ligands as well as with the cytoskeleton. These have been implicated in cell-to-cell interactions through the extracel-... 

Cells are sometimes cultured in serum-free medium. In this condition, the surface should carry substituents of serum proteins that can directly interact with cells. SAMs of alkanethiols with bioactive ligands have been used to control interactions between the material surface and cells [80-83]. Several bioactive ligands have been tested, including RGD [80], PHSRN [81], and laminin-derived peptides [82, 83]. These ligands were expected to directly interact with cell surface integrins. 

Jalali S, del Pozo MA, Chen K-D, Maio H, Li Y-I, Schwartz MA, Shyy JY-J, Chien S. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci USA. 2001 98 1042-1046. 

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