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Integrator genes

To circumvent this problem, vectors that are based on lentiviruses have been developed. In contrast to prototypic retroviruses, lentiviruses do not require cell division for integration. Gene-therapy vectors have been developed from a broad spectrum of lentiviruses including human immunodeficiency vims (HIV), simian and feline immunodeficiency vims as well as visna/maedi vims. The most widely used lentiviral vector system is based on HIV-1. These vectors can efficiently transduce a broad spectrum of dividing and nondividing cells including neurons, hepatocytes, muscle cells, and hematopoietic stem cells [1,2]. [Pg.532]

A nuclear receptor that is a key transcription factor in adipocytes. It plays a critical role in the control of adipocyte differentiation and is involved in the regulation of the expression of specific adipokines, including leptin and adiponectin. It has anti-inflammatory actions and is the target of the thiazolidinedione drugs. The preintegration complex is a complex of retroviral DNA and proteins that translocates from the cytosol into the nucleus prior to integration. Gene Therapy... [Pg.998]

Li Z, Chan C. Inferring pathways and networks with a Bayesian framework. Fa e/ J2004 18 746-748. Li Z, Chan C. Integrating gene expression and metabolic profiles. J Eiol Chem 2004 279 27124-27137. [Pg.71]

Oral administration of exogenous compounds can induce tissue-specific expression of previously transfected (and integrated) genes and transcription factors. Such compounds typically cause conformational changes in the transcription/activating factors that in turn cause their binding to the promotor linked to the transgene. [Pg.358]

J.H. (2002) Modem Genetic Analysis Integrating Genes and Genomes, W. H. Freeman and Company, New York. [Pg.40]

AA Salyers, NB Shoemaker, AM Stevens, LY Li. Conjugative transposons an unusual and diverse set of integrated gene transfer elements. Microbiol Rev 59 579-590, 1995. [Pg.530]


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