Medroxyprogesterone Insulin

Medroxyprogesterone, while suppressing spermatogenesis, also depresses release of growth hormone induced by insulin or arginine (13). 

Gershberg H, Zorrilla E, Hernandez A, Hulse M. Effects of medroxyprogesterone acetate on serum insulin and growth hormone levels in diabetics and potential diabetics. Obstet Gynecol 1969 33(3) 383-9. 

Medroxyprogesterone acetate Hydrocortisone acetate Insulin, zinc suspension (pork or human source)... 

A small historical study evaluated the effect of DMPA on six patients with either chronic active viral hepatitis or primary biliary cirrhosis. The study showed that DMPA actually improved transaminase levels and the metabolic ability of the liver. The investigators suggested that the immune-modifying properties of medroxyprogesterone may make the hormone a therapeutic alternative [2]. There were limitations in that this was a very small, non-randomised study, and therefore it is difficult to make specific recommendations based on the outcome. Another study of the metabolic effects of DMPA in women who had used the method for five years or more suggested that there was a significant rise in plasma insulin, alkaline phosphatase and morning cortisol levels in the DMPA users [31]. 

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