Experimental methods and instrumentation

In order safely and successfully to carry out an inelastic neutron scattering (INS) experiment, there are five essential components  

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Leniart D S 1979 Instrumentation and experimental methods in double resonance Multiple Electron Resonance Spectroscopy ed M M Doric and J H Freed (New York Plenum) ch 2, pp 5-72... 

As instrumentation and experimental methods improve, the role of NMR screening in drug discovery continues to evolve. Of the various criteria for selecting compounds, it is fair to say that solubility remains the most stringent, but the use of probes with cryogeni-... 

The quality of the available data are generally of a reliable standard, particularly the more recent X-ray diffraction studies. Caution, however, must be exercised when evaluating much of the earlier gas phase work, in view of limitations in both contemporary instrumentation and experimental methods which usually require implicit assumptions about molecular geometry. Such data are generally best assessed in groups, and reliance given to systematic trends rather than absolute values. 

This chapter deals with instrumentation and experimental methods to study gas-phase ion-molecule reactions, especially in relation to ion attachment with alkali metal ions. The obvious tools for this are mass spectrometers and tandem mass spectrometers. These are discussed in Sects. 4.3 and 4.4. Alternatively, gas-phase reactions may be studied in a variety of reaction chambers, either in static mode or in flow systems. Examples of the static reaction chambers are high-pressure MS devices (see Sect. 4.7). Examples of flow devices are flowing afterglow and drift-tube systems (see Sects. 4.5 and 4.6, respectively). However, next to these tools, there are a number of other tools that may be helpful. 

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