Inside-out NMR

The Mobile Universal Surface Explorer (MOUSE) is described as a new-generation, hand-held instrument with exciting potential for use on-line." MOUSE devices are based on the principles of inside-out NMR where open magnet designs are used for measurements within the held. Essentially the unit... 

Fig. 9.3.11 [Jacl] Conceivable uses of inside-out NMR in medicine and process control.

Generally, several protocols are used for the characterization of sohd-catalyzed reactions under batch reaction conditions by NMR spectroscopy. In ex situ experiments, the conversion of reactants adsorbed on the catalyst is carried out in an external oven and stopped after a given reaction time by quenching, for example, in liquid nitrogen. Subsequently, the reaction products formed on the catalyst surface are investigated at room temperature by use of a standard MAS NMR probe. This protocol is repeated with a stepwise increment of the reaction time at the same temperature or with a stepwise increment of the reaction temperature for the same duration. In an in situ experiment, the catalytic conversion of the reactants is measured inside the NMR spectrometer by use of a high-temperature MAS NMR probe. 

Annulene satisfies the Huckel (4n+2) tt electron rule for aromaticity and many of its proper ties indicate aromaticity (Section 11 20) As shown in Figure 13 10a [18]annulene contains two different kinds of protons 12 he on the ring s periphery ( out side ) and 6 reside near the middle of the molecule ( inside ) The 2 1 ratio of outside/inside protons makes it easy to assign the signals in the NMR spectrum The outside protons have a chemical shift 8 of 9 3 ppm which makes them even less shielded than those of benzene The six inside protons on the... 

The purpose of this article is to review studies carried out on hemes incorporated inside the micellar cavity, and examine the effect of micellar interaction on the electronic and structural properties of the heme. A comparison of these results with those on the metalloproteins is clearly in order to assess their suitability as models. The article begins with a general introduction to micellar properties, the incorporation of hemes in the micellar cavity, and then discusses results on hemes inside the micelles with different oxidation and spin states, and stereochemistry. The experimental techniques used in the studies on these aqueous detergent micelles are mostly NMR and optical spectroscopy. The present article has therefore a strong emphasis on NMR spectroscopy, since this technique has been used very extensively and purposefully for studies on hemes inside micellar cavities. 

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