Insecticidal methylcarbamates, toxicological properties

An example of the profound effect which change in physical property may have on the toxicological properties of a methylcarbamate insecticide is made apparent from toxicological data for a series of thiocarbamate derivatives of carbofuran (Table 1) (12). 

Toxicological Properties of IJ-Arylsulfenyl and 1 -Alkylsulfenyl Derivatives of Insecticidal Methylcarbamates... 

The discovery of the Improved toxicological properties of the aryl- and alkylsulfenyl derivatives of methylcarbamate insecticides stimulated examination of other types of derivatives containing an N-S linkage. In most of the cases where highest insecticidal activity is found, the methylcarbamate nitrogen is attached to a sulfur atom which is attached to another nitrogen atom, as shown in the general structure below. 

Toxicological Properties of Insecticidal Methylcarbamates and the Corresponding JN,N -Thiobiscarbamates... 

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