Ingredient compatibility

There is a strong relationship between microemulsion monophasic total area, molecular complementarity and the interface s flexibility. Compatibility between the alkyl chains of the surfactant and oil will influence microemulsion formation by strongly affecting the 

An increase in the alkyl chain length of the compound in the oil will typically decrease its solubility in water (Anton et al, 2008), and consequently reduce the total area of the microemulsion monophasic region. Using the BSO (Bansal-Shah-0 Connell) equation, the maximum solubilization for ionic microemulsions occurs when (Bansal et al., 1980 Garti et al, 1995, 2001 Shiao et al, 1998 Yaghmur et al, 2002)  

However, this equation should be used with caution. Shiao and co-workers (1998) reported that the BSO equation failed if the microemulsion contained components with branched alkyl chains, as these decreased the packing order of the hydrocarbons in the interface compared to linear alkyl chains. Garti and co-workers (1995, 2000a) showed that the BSO equation was valid for non-ionic surfactants in five-component microemulsions only when the surfactant (alcohol) exhibited limited solubility in both the aqueous and oil phases. 

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A constitutively hydrophobic food fat is called upon to perform in a hydrophilic environment, suggesting the most important physical property to be its emulsifying capacity. Simultaneously, the fat is ingredient-compatible, heat-stable, and confers a smooth oral sensation. The basic assignment of a fat replacer is to mimic these properties through substitution for the fat s viscosity, texture, and the slippery, creamy, lubricious mouthfeel (Glicksman, 1991). One of the earliest fat substitutes to perform thus was Simplesse (Roller and Jones, 1996), a protein perceived to be of a creamy texture due to inherent 0.1-3.0-pm-diameter microparticles (Thayer, 1992). 

The big challenge is the ingredient compatibility, especially between enzymes and bleach stability in an aqueous matrix, as well as phase stability. In the latter case, it is possible for various... 

Proceedings of the Symposia on Compatibility of Plastics and Other Materials with Explosives, Propellants and Pyrotechnics and Processing of Propellants, Explosives, and Ingredients, ADPA, Washiagton, D.C. 

The selection of excipient ingredients is important. These must be both chemically and physically compatible with the dmg moiety and cannot negatively affect product stabihty or therapeutic performance, ie, bio avadabihty. A comprehensive hst of various types of excipient ingredients, with comment upon usage, is available (16). 

Rhovanil Extra Pure is the standard mesh, multipurpose quaUty of food-grade extra pure vanillin. Its broad particle-size distribution shows a versatile granulometry, compatible with a wide range of granulometric profiles from any other ingredients, and allows a homogeneous powder mixabiUty, even at low content in a given blend. 

Acrylonitrile-butadiene rubber (also called nitrile or nitrile butadiene rubber) was commercially available in 1936 under the name Buna-N. It was obtained by emulsion polymerization of acrylonitrile and butadiene. During World War II, NBR was used to replace natural rubber. After World War II, NBR was still used due to its excellent properties, such as high oil and plasticizer resistance, excellent heat resistance, good adhesion to metallic substrates, and good compatibility with several compounding ingredients. 

Plasticizers reduce hardness, enhance tack and reduce cost in rubber base adhesive formulations. A plasticizer must be easily miscible and highly compatible with other ingredients in the formulations and with the surfaces to which the adhesive is applied. The compatibility and miscibility of plasticizers can be estimated from the solubility parameter values. Most of plasticizers have solubility parameters ranging between 8.5 and 10.5 hildebrands. However, the high miscibility and compatibility also lead to easier diffusion of the plasticizer to the surface, decreasing the adhesion properties. Therefore, plasticizers should be carefully selected and generally combinations of two or more of them are used. 

NBR is a polar polymer and shows superior compatibility with resins as compared to other elastomers. The major ingredients, in addition to the elastomer, for the NBR adhesives are given below. 

Many criteria must be met by raw materials before being selected for a toiletry product skin and eye compatibility, availability, price, biodegradability, ease of use, and compatibility with other finished product ingredients. Sulfosuccinates meet most if not all criteria. 

There shall be a written assessment of stability based at least on testing or examination of the drug product for compatibility of the ingredients, and based on marketing experience with the drug product to indicate that there is no degradation of the product for the normal or expected period of use. 

Assist the widely dissimilar ingredients used in a rubber compound to coalesce and mix into a homogeneous uniform processable mass. Homogenisers are low-MW polymeric resin blends. The homogenising resin blend contains portions that are compatible with aliphatic, naphthenic and aromatic parts of the elastomers in a blend and higher-MW homologues of the plasticisers. They have a wetting effect. Fatty acid derivatives and phenolic resins are used. 

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