Infusions, grades

In another study of 19 patients with complete or near-complete (TIMI grade 0 or 1) middle cerebral artery (MCA) occlusion, combination therapy with reduced-dose rt-PA and tirofiban infusion was associated with recanalization in 68% of patients, significant reductions of MRI ischemic lesion volumes, and substantial clinical improvement (median NIHSS change from 17 at baseline to 2 after treatment, p = 0.002). No cases of sICH occurred. 

Intravesical infusion of linear PEI/pDNA polyplexes was evaluated in patients with superficial bladder cancer where intravesical therapy with bacillus Calmette-Guerin had failed [6, 224]. Patients had low grade superficial bladder cancer, which expressed H19. The therapeutic pDNA contains H19 gene regulatory sequences that drive the expression of an intracellular toxin. Escalating doses of 2-20 mg plasmid per intravesical treatment were applied, with responders continuing to receive polyplexes once a month every month for 1 year. The treatment resulted in complete ablation of the marker tumor, without any new tumors in four of the 18 patients (22% overall complete response rate). Eight of the 18 patients (44%) had complete marker tumor ablation or a 50% reduction of the marker lesion. 

Based on encouraging results from an early pilot study completed by Rush-Presbyte-rian-St. Luke s Medical Center, ECOG evaluated previously irradiated patients who presented with locally recurrent and/or metastatic disease (81). Patients received seven cycles of cisplatin (60 mg/m2, d 1), continuous infusion 5-FU (800 mg/m2, d 1-5), and standard daily radiotherapy (d 1-5) to be repeated every other week. All patients developed grade 2/3 mucositis. Clinically, the ORR was 74% (48% CR, 24% PR). Median TTP was 5 mo. Of interest were three patients that remained disease-free at 44 mo (T2N0), 86 mo (T0N2), and 88 mo (T2N0). 

Epoxies can cure in deep sections and are useful in potting and deep-section sealing applications. They adhere well to different substrates and therefore are used in the general assembly of many medical devices. A clear, medical-grade, low-viscosity epoxy adhesive has proved useful in the fabrication of access ports that are implanted beneath the skin of patients who require multiple infusions.21... 

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