Infrared and Raman Spectroscopy of Cartilage

Cartilage tissue plays a significant role in the musculoskeletal system because of its proximity to bone, and its roles in long bone formation and in diseases such 

Both the collagen fiber orientation and the overall composition of articular cartilage are heterogeneous in the axial direction, and thus contribute to the distinction of three zones of articular cartilage  

Raman and visible spectroscopies [87]. Whilst the vibrational spectroscopic examination of type I collagen has been more extensive than that of type 11 collagen [88-93], the same methods can be used to examine type II collagen structures in tissue, to identify pathological tissues and to monitor fiber tension [94—101]. 

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