Influence of Surfactants on Intestinal Permeability

The effects of surfactant on the solubility and dissolution rate of poorly soluble drugs are well characterized. In general, the surfactant increases both solubility and dissolution rate even if the increment in dissolution rate is less pronounced due to the low diffusivity of the drug loaded into the micelle [9-16]. 

In order to explore the effects of surfactants on the gastrointestinal tract, absorption experiments (with families of homologous or structurally related compounds) were performed in absence and in the presence of surfactants and with the xeno- 

The experiments were performed in stomach, small intestine, and colon. In order to establish a general hypothesis suitable for different drugs and surfactants, the research was performed including anionic, cationic, and neutral surfactants as well as drugs with acidic, alkaline, neutral or amphoteric character [22-25]. 

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