Infectious disease strategies

Centers for Disease Control and Prevention. (2002). Protecting the nation s health in an era of globalization CDC s global infectious disease strategy. Retrieved November 30, 2004, from http //www.cdc.gov/globalidplan/globalJd plan.pdf... 

In sum, RNAi clearly has the potential to change the nucleic-based therapies for cancer, infectious diseases, and many other diseases. However, the universality of this approach, the types of genes that can be silenced using these strategies in human cells, remain unknown to date. 

Enyzme catalysis is thus essential for all life. Hence the selective inhibition of critical enzymes of infectious organisms (e.g., viruses, bacteria, and multicellular parasites) is an attractive means of chemotherapeutic intervention for infectious diseases. This strategy is well represented in modem medicine, with a significant portion of antiviral, antibiotic, and antiparasitic drugs in clinical use today deriving their therapeutic efficacy through selective enzyme inhibition (see Table 1.1 for some examples). 

Kelly, C. G., and Younson, J. S. (2000). Anti-adhesive strategies in the prevention of infectious disease at mucosal surfaces. Expert. Opin. Investig. Drugs 9,1711-1712. 

Sader HS, Gales AC. (2001) Emerging strategies in infectious diseases New carbapenem and trinem antibacterial agents. Drugs 61 553-564. 

Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Novel Treatments for Infectious Diseases... 

Novel Strategies toward the Development of Vaccines against Infectious Diseases... 

The remainder of this paper shall present general principles, examples of applications, and an evaluation of capabilities and limitations of sensitization of plants as a strategy for defense against infectious diseases and damage from other pests. 

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